Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies
(2011) In Stroke: a journal of cerebral circulation 42(1). p.214-216- Abstract
- Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples... (More)
- Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1790869
- author
- Olsson, Sandra ; Melander, Olle LU ; Jood, Katarina ; Smith, Gustav LU ; Lövkvist, Håkan LU ; Sjögren, Marketa LU ; Engström, Gunnar LU ; Norrving, Bo LU ; Lindgren, Arne LU and Jern, Christina
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stroke, single-nucleotide polymorphism, genetic association studies
- in
- Stroke: a journal of cerebral circulation
- volume
- 42
- issue
- 1
- pages
- 214 - 216
- publisher
- American Heart Association
- external identifiers
-
- wos:000285636400043
- scopus:79451468882
- pmid:21148441
- ISSN
- 1524-4628
- DOI
- 10.1161/STROKEAHA.110.594010
- language
- English
- LU publication?
- yes
- id
- 8da49030-af23-4c4a-b1a6-0058485b3bb9 (old id 1790869)
- date added to LUP
- 2016-04-01 14:02:58
- date last changed
- 2024-01-09 22:08:03
@article{8da49030-af23-4c4a-b1a6-0058485b3bb9, abstract = {{Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)}}, author = {{Olsson, Sandra and Melander, Olle and Jood, Katarina and Smith, Gustav and Lövkvist, Håkan and Sjögren, Marketa and Engström, Gunnar and Norrving, Bo and Lindgren, Arne and Jern, Christina}}, issn = {{1524-4628}}, keywords = {{stroke; single-nucleotide polymorphism; genetic association studies}}, language = {{eng}}, number = {{1}}, pages = {{214--216}}, publisher = {{American Heart Association}}, series = {{Stroke: a journal of cerebral circulation}}, title = {{Genetic Variant on Chromosome 12p13 Does Not Show Association to Ischemic Stroke in 3 Swedish Case-Control Studies}}, url = {{http://dx.doi.org/10.1161/STROKEAHA.110.594010}}, doi = {{10.1161/STROKEAHA.110.594010}}, volume = {{42}}, year = {{2011}}, }