Maternal Autoimmune Thyroid Disease and the Fetal Immune System.
(2011) In Experimental and Clinical Endocrinology & Diabetes 119(7). p.445-450- Abstract
- OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to... (More)
- OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to mothers with autoimmune thyroiditis (AIT) (n=31) and to healthy mothers (n=76) and titers of thyroid autoantibodies were determined in cord blood and in maternal peripheral blood at delivery. RESULTS: We found an increase (almost 30%) in the frequency of cord blood natural killer (NK) cells (p=0.0016) and a minor increase in the subset of T cells expressing NK markers (p=0.028), in children born to AIT mothers. There were no detectable differences in the phenotype or frequency of cord blood memory/activated T cells, including CD4 (+)CD25 (+) T cells, between the 2 groups. The levels of pro-inflammatory cytokines TNF-α, IL-10, IL-12p70, IFN-γ and IL-1β were significantly decreased in offspring of AIT mothers as compared to healthy controls. CONCLUSIONS: Maternal thyroid autoimmunity and transplacental passage of autoantibodies against thyroid antigens may affect the generation or expansion of cells with NK activity and the secretion of inflammatory cytokines. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008168
- author
- Svensson, J ; Oderup, C ; Silver, Christina LU ; Uvebrant, K ; Hallengren, Bengt LU ; Ericsson, U B ; Arvastsson, Jeanette LU ; Danska, J S ; Lantz, Mikael LU and Cilio, Corrado LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental and Clinical Endocrinology & Diabetes
- volume
- 119
- issue
- 7
- pages
- 445 - 450
- publisher
- Georg Thieme Verlag
- external identifiers
-
- wos:000294649600011
- pmid:21667438
- scopus:79960156817
- pmid:21667438
- ISSN
- 1439-3646
- DOI
- 10.1055/s-0031-1279741
- language
- English
- LU publication?
- yes
- id
- b763026b-0daf-4108-8589-090ad243c3d2 (old id 2008168)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21667438?dopt=Abstract
- date added to LUP
- 2016-04-01 10:57:04
- date last changed
- 2024-01-07 05:01:28
@article{b763026b-0daf-4108-8589-090ad243c3d2, abstract = {{OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmune thyroid disease later in life. The aim of this study was to identify immunological changes in children born to mothers with thyroid autoimmunity that may be related to in utero exposure to autoantibodies. DESIGN AND METHOD: Open label prospective analysis of cord blood lymphocytes and serum cytokines by Flow Cytometry in children born to mothers with autoimmune thyroiditis (AIT) (n=31) and to healthy mothers (n=76) and titers of thyroid autoantibodies were determined in cord blood and in maternal peripheral blood at delivery. RESULTS: We found an increase (almost 30%) in the frequency of cord blood natural killer (NK) cells (p=0.0016) and a minor increase in the subset of T cells expressing NK markers (p=0.028), in children born to AIT mothers. There were no detectable differences in the phenotype or frequency of cord blood memory/activated T cells, including CD4 (+)CD25 (+) T cells, between the 2 groups. The levels of pro-inflammatory cytokines TNF-α, IL-10, IL-12p70, IFN-γ and IL-1β were significantly decreased in offspring of AIT mothers as compared to healthy controls. CONCLUSIONS: Maternal thyroid autoimmunity and transplacental passage of autoantibodies against thyroid antigens may affect the generation or expansion of cells with NK activity and the secretion of inflammatory cytokines.}}, author = {{Svensson, J and Oderup, C and Silver, Christina and Uvebrant, K and Hallengren, Bengt and Ericsson, U B and Arvastsson, Jeanette and Danska, J S and Lantz, Mikael and Cilio, Corrado}}, issn = {{1439-3646}}, language = {{eng}}, number = {{7}}, pages = {{445--450}}, publisher = {{Georg Thieme Verlag}}, series = {{Experimental and Clinical Endocrinology & Diabetes}}, title = {{Maternal Autoimmune Thyroid Disease and the Fetal Immune System.}}, url = {{https://lup.lub.lu.se/search/files/2262591/2173807.pdf}}, doi = {{10.1055/s-0031-1279741}}, volume = {{119}}, year = {{2011}}, }