The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer
(2019) In Anticancer research 39(4). p.1661-1666- Abstract
Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with... (More)
Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.
(Less)
- author
- Hu, Dingyuan LU ; Ansari, Daniel LU ; Bauden, Monika LU ; Zhou, Qimin LU and Andersson, Roland LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarker, Calcium-activated chloride channel regulator 1, cancer, CLCA1, review
- in
- Anticancer research
- volume
- 39
- issue
- 4
- pages
- 6 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:30952704
- scopus:85064486595
- ISSN
- 1791-7530
- DOI
- 10.21873/anticanres.13271
- language
- English
- LU publication?
- yes
- id
- 20252a84-50ff-480c-8e54-fe0bc07d39f1
- date added to LUP
- 2019-05-03 12:48:34
- date last changed
- 2024-10-01 21:35:27
@article{20252a84-50ff-480c-8e54-fe0bc07d39f1, abstract = {{<p>Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.</p>}}, author = {{Hu, Dingyuan and Ansari, Daniel and Bauden, Monika and Zhou, Qimin and Andersson, Roland}}, issn = {{1791-7530}}, keywords = {{biomarker; Calcium-activated chloride channel regulator 1; cancer; CLCA1; review}}, language = {{eng}}, number = {{4}}, pages = {{1661--1666}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer}}, url = {{http://dx.doi.org/10.21873/anticanres.13271}}, doi = {{10.21873/anticanres.13271}}, volume = {{39}}, year = {{2019}}, }