Stem cell research in stroke: how far from the clinic?
Lindvall, Olle LU and Kokaia, Zaal LU
(2011)
In Stroke: a journal of cerebral circulation
42(8).
p.2369-2375
- Abstract
- Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058668
- author
- Lindvall, Olle
LU
and Kokaia, Zaal
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transplantation, stroke recovery, stem cells, neuroregeneration, neurogenesis, acute stroke, neural stem cell, inflammation
- in
- Stroke: a journal of cerebral circulation
- volume
- 42
- issue
- 8
- pages
- 2369 - 2375
- publisher
- American Heart Association
- external identifiers
-
- wos:000293077400054
- pmid:21757669
- scopus:79961208735
- pmid:21757669
- ISSN
- 1524-4628
- DOI
- 10.1161/STROKEAHA.110.599654
- language
- English
- LU publication?
- yes
- id
- 29564348-b086-481f-af9a-aeb66cf36af3 (old id 2058668)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21757669?dopt=Abstract
- date added to LUP
- 2016-04-01 13:06:48
- date last changed
- 2022-04-13 23:18:34
@article{29564348-b086-481f-af9a-aeb66cf36af3,
abstract = {{Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke.}},
author = {{Lindvall, Olle and Kokaia, Zaal}},
issn = {{1524-4628}},
keywords = {{transplantation; stroke recovery; stem cells; neuroregeneration; neurogenesis; acute stroke; neural stem cell; inflammation}},
language = {{eng}},
number = {{8}},
pages = {{2369--2375}},
publisher = {{American Heart Association}},
series = {{Stroke: a journal of cerebral circulation}},
title = {{Stem cell research in stroke: how far from the clinic?}},
url = {{http://dx.doi.org/10.1161/STROKEAHA.110.599654}},
doi = {{10.1161/STROKEAHA.110.599654}},
volume = {{42}},
year = {{2011}},
}