Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures
(1992) In Brain Research 587(2). p.42-338- Abstract
Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/20be847e-de8e-4921-88cd-f292790656b2
- author
- Bengzon, J LU ; Söderström, S ; Kokaia, Z LU ; Kokaia, M LU ; Ernfors, P ; Persson, H ; Ebendal, T and Lindvall, O LU
- publishing date
- 1992-08-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Cerebral Cortex/anatomy & histology, Kindling, Neurologic/physiology, Male, Nerve Growth Factors/physiology, Prosencephalon/anatomy & histology, Rats, Rats, Inbred Strains, Seizures/metabolism
- in
- Brain Research
- volume
- 587
- issue
- 2
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0026730721
- pmid:1525666
- ISSN
- 0006-8993
- DOI
- 10.1016/0006-8993(92)91016-8
- language
- English
- LU publication?
- no
- id
- 20be847e-de8e-4921-88cd-f292790656b2
- date added to LUP
- 2019-06-25 10:43:58
- date last changed
- 2024-01-01 13:06:49
@article{20be847e-de8e-4921-88cd-f292790656b2, abstract = {{<p>Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.</p>}}, author = {{Bengzon, J and Söderström, S and Kokaia, Z and Kokaia, M and Ernfors, P and Persson, H and Ebendal, T and Lindvall, O}}, issn = {{0006-8993}}, keywords = {{Animals; Cerebral Cortex/anatomy & histology; Kindling, Neurologic/physiology; Male; Nerve Growth Factors/physiology; Prosencephalon/anatomy & histology; Rats; Rats, Inbred Strains; Seizures/metabolism}}, language = {{eng}}, month = {{08}}, number = {{2}}, pages = {{42--338}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures}}, url = {{http://dx.doi.org/10.1016/0006-8993(92)91016-8}}, doi = {{10.1016/0006-8993(92)91016-8}}, volume = {{587}}, year = {{1992}}, }