A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax
(2011) In Acta Pædiatrica 100(11). p.1448-1453- Abstract
- Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2208099
- author
- Brodszki, Nicholas LU ; Länsberg, John-Kalle LU ; Dictor, Michael LU ; Gyllstedt, Erik LU ; Ewers, Sven-Börje LU ; Larsson, Marcus LU and Eklund, Erik LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute respiratory failure, Alpha-interferon therapy, Heparin
- in
- Acta Pædiatrica
- volume
- 100
- issue
- 11
- pages
- 1448 - 1453
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000296421300020
- pmid:21605166
- scopus:80054024069
- pmid:21605166
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2011.02361.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Pathology, (Lund) (013030000), Thoracic Surgery (013230027), Oncology, MV (013035000), Matrix biology (013212025)
- id
- 3fcd22ba-682a-45cf-90f7-6718166af96d (old id 2208099)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21605166?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:00
- date last changed
- 2022-04-27 22:53:03
@article{3fcd22ba-682a-45cf-90f7-6718166af96d, abstract = {{Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.}}, author = {{Brodszki, Nicholas and Länsberg, John-Kalle and Dictor, Michael and Gyllstedt, Erik and Ewers, Sven-Börje and Larsson, Marcus and Eklund, Erik}}, issn = {{1651-2227}}, keywords = {{Acute respiratory failure; Alpha-interferon therapy; Heparin}}, language = {{eng}}, number = {{11}}, pages = {{1448--1453}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Pædiatrica}}, title = {{A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax}}, url = {{http://dx.doi.org/10.1111/j.1651-2227.2011.02361.x}}, doi = {{10.1111/j.1651-2227.2011.02361.x}}, volume = {{100}}, year = {{2011}}, }