HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
(2012) In Diabetes Research and Clinical Practice 95. p.260-264- Abstract
- AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with... (More)
- AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2220566
- author
- Papadopoulou, Anastasia LU ; Lynch, Kristian LU ; Anderberg, Eva LU ; Landin-Olsson, Mona LU ; Jönsson, Ida LU ; Agardh, Carl-David LU ; Lernmark, Åke LU and Berntorp, Kerstin LU
- organization
-
- Celiac Disease and Diabetes Unit (research group)
- Obstetrics and Gynaecology (Lund)
- Medicine, Lund
- Paediatric Endocrinology (research group)
- Department of Clinical Sciences, Malmö
- Translational Muscle Research (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Research and Clinical Practice
- volume
- 95
- pages
- 260 - 264
- publisher
- Elsevier
- external identifiers
-
- wos:000299953900018
- pmid:22104260
- scopus:84856337975
- pmid:22104260
- ISSN
- 1872-8227
- DOI
- 10.1016/j.diabres.2011.10.037
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Paediatric Endocrinology Research Group (013243010), Medicine (Lund) (013230025), Department of Obstetrics and Gynaecology (Lund) (013018000), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510)
- id
- 342c1971-f125-40c4-b88b-c47cd4e7b98e (old id 2220566)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22104260?dopt=Abstract
- date added to LUP
- 2016-04-04 07:27:06
- date last changed
- 2024-03-13 08:29:28
@article{342c1971-f125-40c4-b88b-c47cd4e7b98e, abstract = {{AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development.}}, author = {{Papadopoulou, Anastasia and Lynch, Kristian and Anderberg, Eva and Landin-Olsson, Mona and Jönsson, Ida and Agardh, Carl-David and Lernmark, Åke and Berntorp, Kerstin}}, issn = {{1872-8227}}, language = {{eng}}, pages = {{260--264}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.}}, url = {{http://dx.doi.org/10.1016/j.diabres.2011.10.037}}, doi = {{10.1016/j.diabres.2011.10.037}}, volume = {{95}}, year = {{2012}}, }