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Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc

Axelson, H LU ; Panda, C K and Klein, G (1994) In International Journal of Cancer 56(3). p.21-418
Abstract

The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Cell Line, Chromosome Mapping, DNA, Neoplasm, Genes, Immunoglobulin, Genes, myc, Immunoglobulin Heavy Chains, Leukemia, Lymphocytic, Chronic, B-Cell, Multigene Family, Rats, Rats, Inbred Strains, Restriction Mapping, Translocation, Genetic, Tumor Cells, Cultured
in
International Journal of Cancer
volume
56
issue
3
pages
21 - 418
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0028269951
  • pmid:8314330
ISSN
0020-7136
language
English
LU publication?
yes
id
231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90
date added to LUP
2016-08-09 09:19:28
date last changed
2024-01-04 10:34:21
@article{231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90,
  abstract     = {{<p>The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.</p>}},
  author       = {{Axelson, H and Panda, C K and Klein, G}},
  issn         = {{0020-7136}},
  keywords     = {{Animals; Cell Line; Chromosome Mapping; DNA, Neoplasm; Genes, Immunoglobulin; Genes, myc; Immunoglobulin Heavy Chains; Leukemia, Lymphocytic, Chronic, B-Cell; Multigene Family; Rats; Rats, Inbred Strains; Restriction Mapping; Translocation, Genetic; Tumor Cells, Cultured}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{3}},
  pages        = {{21--418}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc}},
  volume       = {{56}},
  year         = {{1994}},
}