Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc
(1994) In International Journal of Cancer 56(3). p.21-418- Abstract
The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90
- author
- Axelson, H LU ; Panda, C K and Klein, G
- organization
- publishing date
- 1994-02-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Cell Line, Chromosome Mapping, DNA, Neoplasm, Genes, Immunoglobulin, Genes, myc, Immunoglobulin Heavy Chains, Leukemia, Lymphocytic, Chronic, B-Cell, Multigene Family, Rats, Rats, Inbred Strains, Restriction Mapping, Translocation, Genetic, Tumor Cells, Cultured
- in
- International Journal of Cancer
- volume
- 56
- issue
- 3
- pages
- 21 - 418
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8314330
- scopus:0028269951
- ISSN
- 0020-7136
- language
- English
- LU publication?
- yes
- id
- 231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90
- date added to LUP
- 2016-08-09 09:19:28
- date last changed
- 2024-01-04 10:34:21
@article{231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90, abstract = {{<p>The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.</p>}}, author = {{Axelson, H and Panda, C K and Klein, G}}, issn = {{0020-7136}}, keywords = {{Animals; Cell Line; Chromosome Mapping; DNA, Neoplasm; Genes, Immunoglobulin; Genes, myc; Immunoglobulin Heavy Chains; Leukemia, Lymphocytic, Chronic, B-Cell; Multigene Family; Rats; Rats, Inbred Strains; Restriction Mapping; Translocation, Genetic; Tumor Cells, Cultured}}, language = {{eng}}, month = {{02}}, number = {{3}}, pages = {{21--418}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Cancer}}, title = {{Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc}}, volume = {{56}}, year = {{1994}}, }