Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women.
Callréus, Mattias LU ; McGuigan, Fiona LU
and Åkesson, Kristina
LU
(2013)
In Osteoporosis International
24(4).
p.1347-1355
- Abstract
- Lower birth weight has a negative association with adult BMC and body composition in young adult Swedish women.
INTRODUCTION: The aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women.
METHODS: One thousand sixty-one women participated in this cross-sectional population-based study using dual energy X-ray absorptiometry (DXA) to assess bone mineral content (BMC), bone mineral density (BMD), and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), and lean and fat mass). Birth weight data was available for 1,047 women and was categorized into tertiles of low (≤3,180 g),... (More) - Lower birth weight has a negative association with adult BMC and body composition in young adult Swedish women.
INTRODUCTION: The aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women.
METHODS: One thousand sixty-one women participated in this cross-sectional population-based study using dual energy X-ray absorptiometry (DXA) to assess bone mineral content (BMC), bone mineral density (BMD), and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), and lean and fat mass). Birth weight data was available for 1,047 women and was categorized into tertiles of low (≤3,180 g), intermediate (3,181-3,620 g), and high (≥3,621 g) birth weight.
RESULTS: Significant correlations were observed between birth weight and TB-BMC (r = 0.159, p < 0.001), FN-BMC (r = 0.096, p < 0.001), TH-BMC (r = 0.102, p = 0.001), LS-BMC (r = 0.095, p = 0.002), and lean mass (r = 0.215, p < 0.001). No correlation was observed between birth weight and BMD. The estimated magnitude of effect was equivalent to a 0.3-0.5 SD difference in BMC for every 1 kg difference in birth weight (151 g (TB); 0.22 g (FN); 1.5 g (TH), 2.5 kg TB lean mass). The strongest correlations between birth weight and BMC occurred in women with lowest birth weights, although excluding women who weighed <2,500 g at birth, and the correlation remained significant although slightly weaker.
CONCLUSIONS: Women with lower birth weight have lower BMC and less lean and fat mass at the age of 25, independent of current body weight. Lower birth weight has a greater negative influence on bone mass than the positive influence of higher birth weight. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2967009
- author
- Callréus, Mattias
LU
; McGuigan, Fiona
LU
and Åkesson, Kristina
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoporosis International
- volume
- 24
- issue
- 4
- pages
- 1347 - 1355
- publisher
- Springer
- external identifiers
-
- wos:000316639600022
- pmid:22806558
- scopus:84876484957
- ISSN
- 1433-2965
- DOI
- 10.1007/s00198-012-2077-8
- language
- English
- LU publication?
- yes
- id
- d0f671ca-3568-4699-8f2c-d30cbaa37131 (old id 2967009)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22806558?dopt=Abstract
- date added to LUP
- 2016-04-01 10:08:31
- date last changed
- 2024-04-21 04:37:47
@article{d0f671ca-3568-4699-8f2c-d30cbaa37131,
abstract = {{Lower birth weight has a negative association with adult BMC and body composition in young adult Swedish women. <br/><br>
<br/><br>
INTRODUCTION: The aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women. <br/><br>
<br/><br>
METHODS: One thousand sixty-one women participated in this cross-sectional population-based study using dual energy X-ray absorptiometry (DXA) to assess bone mineral content (BMC), bone mineral density (BMD), and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), and lean and fat mass). Birth weight data was available for 1,047 women and was categorized into tertiles of low (≤3,180 g), intermediate (3,181-3,620 g), and high (≥3,621 g) birth weight. <br/><br>
<br/><br>
RESULTS: Significant correlations were observed between birth weight and TB-BMC (r = 0.159, p < 0.001), FN-BMC (r = 0.096, p < 0.001), TH-BMC (r = 0.102, p = 0.001), LS-BMC (r = 0.095, p = 0.002), and lean mass (r = 0.215, p < 0.001). No correlation was observed between birth weight and BMD. The estimated magnitude of effect was equivalent to a 0.3-0.5 SD difference in BMC for every 1 kg difference in birth weight (151 g (TB); 0.22 g (FN); 1.5 g (TH), 2.5 kg TB lean mass). The strongest correlations between birth weight and BMC occurred in women with lowest birth weights, although excluding women who weighed <2,500 g at birth, and the correlation remained significant although slightly weaker. <br/><br>
<br/><br>
CONCLUSIONS: Women with lower birth weight have lower BMC and less lean and fat mass at the age of 25, independent of current body weight. Lower birth weight has a greater negative influence on bone mass than the positive influence of higher birth weight.}},
author = {{Callréus, Mattias and McGuigan, Fiona and Åkesson, Kristina}},
issn = {{1433-2965}},
language = {{eng}},
number = {{4}},
pages = {{1347--1355}},
publisher = {{Springer}},
series = {{Osteoporosis International}},
title = {{Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women.}},
url = {{https://lup.lub.lu.se/search/files/1598357/3460860.pdf}},
doi = {{10.1007/s00198-012-2077-8}},
volume = {{24}},
year = {{2013}},
}