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Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel

Dencker, Magnus LU ; Björgell, Ola LU and Hlebowicz, Joanna LU (2019) In BMC Research Notes 12(1).
Abstract

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%),... (More)

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009)

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Olink, Proseek Oncology II
in
BMC Research Notes
volume
12
issue
1
article number
199
publisher
BioMed Central (BMC)
external identifiers
  • pmid:30940215
  • scopus:85063808007
ISSN
1756-0500
DOI
10.1186/s13104-019-4237-9
language
English
LU publication?
yes
id
2b3deac8-e4ee-4b80-8166-ee37fae8fec5
date added to LUP
2019-04-23 11:27:58
date last changed
2025-10-14 11:43:01
@article{2b3deac8-e4ee-4b80-8166-ee37fae8fec5,
  abstract     = {{<p>Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Results: The levels of 6 biomarkers decreased significantly (P &lt; 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P &lt; 0.001) 120 min after food intake. One biomarker was significantly increased (P &lt; 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009)</p>}},
  author       = {{Dencker, Magnus and Björgell, Ola and Hlebowicz, Joanna}},
  issn         = {{1756-0500}},
  keywords     = {{Olink; Proseek Oncology II}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Research Notes}},
  title        = {{Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel}},
  url          = {{http://dx.doi.org/10.1186/s13104-019-4237-9}},
  doi          = {{10.1186/s13104-019-4237-9}},
  volume       = {{12}},
  year         = {{2019}},
}