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C4b-binding protein (C4BP) activates B cells through the CD40 receptor

Brodeur, SR ; Angelini, F ; Bacharier, LB ; Blom, Anna LU orcid ; Mizoguchi, E ; Fujiwara, H ; Plebani, A ; Notarangelo, LD ; Dahlbäck, Björn LU and Tsitsikov, E , et al. (2003) In Immunity 18(6). p.837-848
Abstract
We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
18
issue
6
pages
837 - 848
publisher
Cell Press
external identifiers
  • pmid:12818164
  • wos:000183767700013
  • scopus:0038503986
ISSN
1074-7613
language
English
LU publication?
yes
id
f8b64d40-ece0-4513-b242-003d3754cbaa (old id 308125)
alternative location
http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493
date added to LUP
2016-04-01 11:51:16
date last changed
2022-04-28 21:01:13
@article{f8b64d40-ece0-4513-b242-003d3754cbaa,
  abstract     = {{We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.}},
  author       = {{Brodeur, SR and Angelini, F and Bacharier, LB and Blom, Anna and Mizoguchi, E and Fujiwara, H and Plebani, A and Notarangelo, LD and Dahlbäck, Björn and Tsitsikov, E and Geha, RS}},
  issn         = {{1074-7613}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{837--848}},
  publisher    = {{Cell Press}},
  series       = {{Immunity}},
  title        = {{C4b-binding protein (C4BP) activates B cells through the CD40 receptor}},
  url          = {{http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493}},
  volume       = {{18}},
  year         = {{2003}},
}