Eradication of nasopharyngeal carriage of penicillin-non-susceptible Streptococcus pneumoniae-is it possible?
(2012) In Scandinavian Journal of Infectious Diseases 44(12). p.909-914- Abstract
- Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter... (More)
- Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter than 7 days after treatment completion, were required for the carriage to be considered eradicated. Results: Out of 125 children, 71 received treatment with rifampicin in combination with amoxicillin (n = 44), erythromycin (n = 22), or clindamycin (n = 5) for 7 days. Eradication treatment was successful in 91.5% of the children. Six children (8.5%) had treatment failure with amoxicillin and rifampicin; 3 were found by late follow-up. There was a trend towards a better outcome with erythromycin and clindamycin combinations in comparison to amoxicillin. Conclusions: Eradication therapy was successful, but a proper follow-up is essential. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3123859
- author
- Hellberg, Maria LU ; Johansson, Sandra ; Ahl, Jonas LU ; Odenholt, Inga LU ; Holmdahl, Torsten LU ; Ringberg, Håkan ; Nilsson Wimar, Percy LU and Norrgren, Hans LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 44
- issue
- 12
- pages
- 909 - 914
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000311127800003
- pmid:22991948
- scopus:84874184479
- pmid:22991948
- ISSN
- 1651-1980
- DOI
- 10.3109/00365548.2012.697636
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Geriatric Medicine (013040040), Division of Infection Medicine (SUS) (013008000), Preventive Paediatrics (013243030), Infectious Diseases Research Unit (013242010)
- id
- c9d86865-911c-45b9-ab16-1f0752e4e31d (old id 3123859)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22991948?dopt=Abstract
- date added to LUP
- 2016-04-04 09:31:39
- date last changed
- 2022-01-29 18:16:23
@article{c9d86865-911c-45b9-ab16-1f0752e4e31d, abstract = {{Background: The South Swedish Pneumococcal Intervention Project (SSPIP) was started in 1995 with the aim of limiting the spread of penicillin-non-susceptible pneumococci (PNSP) in Skåne County, Sweden. As part of the SSPIP, eradication therapy with rifampicin in combination with 1 more antibiotic was considered on a social indication after prolonged carriage of 2-3 months. Methods: In this retrospective study, 125 medical records were analyzed. Children aged 0-10 y referred for eradication therapy in Malmö and Lund, due to a prolonged nasopharyngeal carriage of PNSP with a penicillin G minimum inhibitory concentration of ≥ 0.5 mg/l, between the y 1997 and 2011 were included. Two consecutive negative cultures, with the second one no shorter than 7 days after treatment completion, were required for the carriage to be considered eradicated. Results: Out of 125 children, 71 received treatment with rifampicin in combination with amoxicillin (n = 44), erythromycin (n = 22), or clindamycin (n = 5) for 7 days. Eradication treatment was successful in 91.5% of the children. Six children (8.5%) had treatment failure with amoxicillin and rifampicin; 3 were found by late follow-up. There was a trend towards a better outcome with erythromycin and clindamycin combinations in comparison to amoxicillin. Conclusions: Eradication therapy was successful, but a proper follow-up is essential.}}, author = {{Hellberg, Maria and Johansson, Sandra and Ahl, Jonas and Odenholt, Inga and Holmdahl, Torsten and Ringberg, Håkan and Nilsson Wimar, Percy and Norrgren, Hans}}, issn = {{1651-1980}}, language = {{eng}}, number = {{12}}, pages = {{909--914}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Eradication of nasopharyngeal carriage of penicillin-non-susceptible Streptococcus pneumoniae-is it possible?}}, url = {{http://dx.doi.org/10.3109/00365548.2012.697636}}, doi = {{10.3109/00365548.2012.697636}}, volume = {{44}}, year = {{2012}}, }