Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
(2012) In PLoS ONE 7(9).- Abstract
- Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3161219
- author
- Vaapil, Marica LU ; Helczynska, Karolina LU ; Villadsen, René ; Petersen, Ole W ; Johansson, Elisabet LU ; Beckman, Siv LU ; Larsson, Christer LU ; Påhlman, Sven LU and Jögi, Annika LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hypoxia, Breast cancer, differentiation, epithelial cells
- in
- PLoS ONE
- volume
- 7
- issue
- 9
- article number
- e46543
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000309973900183
- pmid:23029547
- scopus:84866984248
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0046543
- language
- English
- LU publication?
- yes
- id
- 088dcd0e-5e2b-40f0-a26f-5f089f466440 (old id 3161219)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23029547?dopt=Abstract
- date added to LUP
- 2016-04-04 09:26:11
- date last changed
- 2022-01-29 17:49:22
@article{088dcd0e-5e2b-40f0-a26f-5f089f466440, abstract = {{Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.}}, author = {{Vaapil, Marica and Helczynska, Karolina and Villadsen, René and Petersen, Ole W and Johansson, Elisabet and Beckman, Siv and Larsson, Christer and Påhlman, Sven and Jögi, Annika}}, issn = {{1932-6203}}, keywords = {{hypoxia; Breast cancer; differentiation; epithelial cells}}, language = {{eng}}, number = {{9}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.}}, url = {{https://lup.lub.lu.se/search/files/5323696/3216672.pdf}}, doi = {{10.1371/journal.pone.0046543}}, volume = {{7}}, year = {{2012}}, }