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Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.

Sehic, Daniel LU ; Forslund, Ola LU ; Sandén, Emma LU ; Holmquist Mengelbier, Linda LU ; Karlsson, Jenny LU ; Bzhalava, Davit LU ; Ekström, Johanna LU ; Warenholt, Janina ; Darabi, Anna LU and Dillner, Joakim LU , et al. (2013) In Pediatric Blood & Cancer 60(9). p.91-93
Abstract
Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Blood & Cancer
volume
60
issue
9
pages
91 - 93
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000321703900059
  • pmid:23572312
  • scopus:84880363509
  • pmid:23572312
ISSN
1545-5017
DOI
10.1002/pbc.24535
language
English
LU publication?
yes
id
49197cd1-1c5d-4aa1-abec-bbd8ac527076 (old id 3733965)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23572312?dopt=Abstract
date added to LUP
2016-04-01 10:25:51
date last changed
2022-01-25 23:09:22
@article{49197cd1-1c5d-4aa1-abec-bbd8ac527076,
  abstract     = {{Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.}},
  author       = {{Sehic, Daniel and Forslund, Ola and Sandén, Emma and Holmquist Mengelbier, Linda and Karlsson, Jenny and Bzhalava, Davit and Ekström, Johanna and Warenholt, Janina and Darabi, Anna and Dillner, Joakim and Øra, Ingrid and Gisselsson Nord, David}},
  issn         = {{1545-5017}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{91--93}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Blood & Cancer}},
  title        = {{Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.}},
  url          = {{http://dx.doi.org/10.1002/pbc.24535}},
  doi          = {{10.1002/pbc.24535}},
  volume       = {{60}},
  year         = {{2013}},
}