Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
(2013) In Pediatric Blood & Cancer 60(9). p.91-93- Abstract
- Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3733965
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Blood & Cancer
- volume
- 60
- issue
- 9
- pages
- 91 - 93
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000321703900059
- pmid:23572312
- scopus:84880363509
- pmid:23572312
- ISSN
- 1545-5017
- DOI
- 10.1002/pbc.24535
- language
- English
- LU publication?
- yes
- id
- 49197cd1-1c5d-4aa1-abec-bbd8ac527076 (old id 3733965)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23572312?dopt=Abstract
- date added to LUP
- 2016-04-01 10:25:51
- date last changed
- 2022-01-25 23:09:22
@article{49197cd1-1c5d-4aa1-abec-bbd8ac527076, abstract = {{Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.}}, author = {{Sehic, Daniel and Forslund, Ola and Sandén, Emma and Holmquist Mengelbier, Linda and Karlsson, Jenny and Bzhalava, Davit and Ekström, Johanna and Warenholt, Janina and Darabi, Anna and Dillner, Joakim and Øra, Ingrid and Gisselsson Nord, David}}, issn = {{1545-5017}}, language = {{eng}}, number = {{9}}, pages = {{91--93}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Pediatric Blood & Cancer}}, title = {{Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.}}, url = {{http://dx.doi.org/10.1002/pbc.24535}}, doi = {{10.1002/pbc.24535}}, volume = {{60}}, year = {{2013}}, }