Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
(2013) In Molecular and Cellular Endocrinology 375(1-2). p.35-42- Abstract
- Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and CDK9 were highly expressed, while CDK1 was expressed at low level. High expression of CDK18 was observed in diabetic islets. Of the CDKIs, CDKN1A expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of CDKN1A, CDKN2A, CCNI2, CDK3 and CDK16 was correlated with age. Finally, eight SNPs in these genes... (More)
- Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and CDK9 were highly expressed, while CDK1 was expressed at low level. High expression of CDK18 was observed in diabetic islets. Of the CDKIs, CDKN1A expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of CDKN1A, CDKN2A, CCNI2, CDK3 and CDK16 was correlated with age. Finally, eight SNPs in these genes were associated with T2D in the DIAGRAM database. Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3804127
- author
- Taneera, Jalal LU ; Fadista, Joao LU ; Ahlqvist, Emma LU ; Zhang, Mengze ; Wierup, Nils LU ; Renström, Erik LU and Groop, Leif LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular and Cellular Endocrinology
- volume
- 375
- issue
- 1-2
- pages
- 35 - 42
- publisher
- Elsevier
- external identifiers
-
- wos:000322054600005
- pmid:23707792
- scopus:84878699515
- ISSN
- 1872-8057
- DOI
- 10.1016/j.mce.2013.05.003
- language
- English
- LU publication?
- yes
- id
- da6bde68-7d96-4f01-8baf-9b3e3b0f532d (old id 3804127)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23707792?dopt=Abstract
- date added to LUP
- 2016-04-01 11:07:37
- date last changed
- 2024-04-22 04:28:35
@article{da6bde68-7d96-4f01-8baf-9b3e3b0f532d, abstract = {{Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and CDK9 were highly expressed, while CDK1 was expressed at low level. High expression of CDK18 was observed in diabetic islets. Of the CDKIs, CDKN1A expression was higher in diabetic islets in both microarray and qRT-PCR. Expression of CDKN1A, CDKN2A, CCNI2, CDK3 and CDK16 was correlated with age. Finally, eight SNPs in these genes were associated with T2D in the DIAGRAM database. Our data provide a comprehensive expression pattern of cell cycle genes in human islets. More human studies are required to confirm and reproduce animal studies.}}, author = {{Taneera, Jalal and Fadista, Joao and Ahlqvist, Emma and Zhang, Mengze and Wierup, Nils and Renström, Erik and Groop, Leif}}, issn = {{1872-8057}}, language = {{eng}}, number = {{1-2}}, pages = {{35--42}}, publisher = {{Elsevier}}, series = {{Molecular and Cellular Endocrinology}}, title = {{Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.}}, url = {{http://dx.doi.org/10.1016/j.mce.2013.05.003}}, doi = {{10.1016/j.mce.2013.05.003}}, volume = {{375}}, year = {{2013}}, }