A high-stringency blueprint of the human proteome
(2020) In Nature Communications 11(1).- Abstract
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human... (More)
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
(Less)
- author
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 11
- issue
- 1
- article number
- 5301
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33067450
- scopus:85092744472
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-020-19045-9
- language
- English
- LU publication?
- yes
- id
- 386225d4-c788-4d7a-a52c-6c832e7face9
- date added to LUP
- 2020-11-05 11:32:22
- date last changed
- 2024-04-17 18:31:03
@article{386225d4-c788-4d7a-a52c-6c832e7face9,
abstract = {{<p>The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.</p>}},
author = {{Adhikari, Subash and Nice, Edouard C. and Deutsch, Eric W. and Lane, Lydie and Omenn, Gilbert S. and Pennington, Stephen R. and Paik, Young Ki and Overall, Christopher M. and Corrales, Fernando J. and Cristea, Ileana M. and Van Eyk, Jennifer E. and Uhlén, Mathias and Lindskog, Cecilia and Chan, Daniel W. and Bairoch, Amos and Waddington, James C. and Justice, Joshua L. and LaBaer, Joshua and Rodriguez, Henry and He, Fuchu and Kostrzewa, Markus and Ping, Peipei and Gundry, Rebekah L. and Stewart, Peter and Srivastava, Sanjeeva and Srivastava, Sudhir and Nogueira, Fabio C.S. and Domont, Gilberto B. and Vandenbrouck, Yves and Lam, Maggie P.Y. and Wennersten, Sara and Vizcaino, Juan Antonio and Wilkins, Marc and Schwenk, Jochen M. and Lundberg, Emma and Bandeira, Nuno and Marko-Varga, Gyorgy and Weintraub, Susan T. and Pineau, Charles and Kusebauch, Ulrike and Moritz, Robert L. and Ahn, Seong Beom and Palmblad, Magnus and Snyder, Michael P. and Aebersold, Ruedi and Baker, Mark S.}},
issn = {{2041-1723}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{A high-stringency blueprint of the human proteome}},
url = {{http://dx.doi.org/10.1038/s41467-020-19045-9}},
doi = {{10.1038/s41467-020-19045-9}},
volume = {{11}},
year = {{2020}},
}