Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life
(2023) In Movement Disorders Clinical Practice 10(3). p.392-398- Abstract
Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and... (More)
Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept. Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (rs = 0.60, rs = 0.54, rs = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (rs = 0.39, rs = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001). Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.
(Less)
- author
- Norlin, Jenny M.
; Kellerborg, Klas
; Persson, Ulf
; Åström, Daniel Oudin
LU
; Hagell, Peter
LU
; Martinez-Martin, Pablo
and Odin, Per
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CISI-PD, EQ-5D, Parkinson's disease, PDQ-8
- in
- Movement Disorders Clinical Practice
- volume
- 10
- issue
- 3
- pages
- 392 - 398
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:36949801
- scopus:85147036374
- ISSN
- 2330-1619
- DOI
- 10.1002/mdc3.13649
- language
- English
- LU publication?
- yes
- id
- 387ca1dd-8be1-470a-b9a4-a617249940b1
- date added to LUP
- 2023-02-14 11:33:36
- date last changed
- 2024-09-06 08:03:07
@article{387ca1dd-8be1-470a-b9a4-a617249940b1, abstract = {{<p>Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept. Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (r<sub>s</sub> = 0.60, r<sub>s</sub> = 0.54, r<sub>s</sub> = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (r<sub>s</sub> = 0.39, r<sub>s</sub> = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001). Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.</p>}}, author = {{Norlin, Jenny M. and Kellerborg, Klas and Persson, Ulf and Åström, Daniel Oudin and Hagell, Peter and Martinez-Martin, Pablo and Odin, Per}}, issn = {{2330-1619}}, keywords = {{CISI-PD; EQ-5D; Parkinson's disease; PDQ-8}}, language = {{eng}}, number = {{3}}, pages = {{392--398}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Movement Disorders Clinical Practice}}, title = {{Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life}}, url = {{http://dx.doi.org/10.1002/mdc3.13649}}, doi = {{10.1002/mdc3.13649}}, volume = {{10}}, year = {{2023}}, }