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Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life

Norlin, Jenny M. ; Kellerborg, Klas ; Persson, Ulf ; Åström, Daniel Oudin LU ; Hagell, Peter LU ; Martinez-Martin, Pablo and Odin, Per LU orcid (2023) In Movement Disorders Clinical Practice 10(3). p.392-398
Abstract

Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and... (More)

Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept. Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (rs = 0.60, rs = 0.54, rs = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (rs = 0.39, rs = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001). Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CISI-PD, EQ-5D, Parkinson's disease, PDQ-8
in
Movement Disorders Clinical Practice
volume
10
issue
3
pages
392 - 398
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85147036374
  • pmid:36949801
ISSN
2330-1619
DOI
10.1002/mdc3.13649
language
English
LU publication?
yes
id
387ca1dd-8be1-470a-b9a4-a617249940b1
date added to LUP
2023-02-14 11:33:36
date last changed
2025-01-11 21:33:47
@article{387ca1dd-8be1-470a-b9a4-a617249940b1,
  abstract     = {{<p>Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept. Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (r<sub>s</sub> = 0.60, r<sub>s</sub> = 0.54, r<sub>s</sub> = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (r<sub>s</sub> = 0.39, r<sub>s</sub> = 0.29) (P values &lt; 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values &lt; 0.001). Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.</p>}},
  author       = {{Norlin, Jenny M. and Kellerborg, Klas and Persson, Ulf and Åström, Daniel Oudin and Hagell, Peter and Martinez-Martin, Pablo and Odin, Per}},
  issn         = {{2330-1619}},
  keywords     = {{CISI-PD; EQ-5D; Parkinson's disease; PDQ-8}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{392--398}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders Clinical Practice}},
  title        = {{Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life}},
  url          = {{http://dx.doi.org/10.1002/mdc3.13649}},
  doi          = {{10.1002/mdc3.13649}},
  volume       = {{10}},
  year         = {{2023}},
}