Intracellular complement and immunometabolism : The advantages of compartmentalization
(2024) In European Journal of Immunology- Abstract
The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is... (More)
The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is currently known about how complement functions in intracellular signal transduction, and outline the functional advantages of a compartmentalized and intracellular complement system.
(Less)
- author
- King, Ben C.
LU
and Blom, Anna M. LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Immunometabolism, Inflammation, Intracellular complement
- in
- European Journal of Immunology
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:38757569
- scopus:85193390903
- ISSN
- 0014-2980
- DOI
- 10.1002/eji.202350813
- language
- English
- LU publication?
- yes
- id
- 39818b64-00dc-4b1a-b5e8-19d52e1dc67f
- date added to LUP
- 2024-06-18 15:37:44
- date last changed
- 2024-08-13 20:28:46
@article{39818b64-00dc-4b1a-b5e8-19d52e1dc67f, abstract = {{<p>The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is currently known about how complement functions in intracellular signal transduction, and outline the functional advantages of a compartmentalized and intracellular complement system.</p>}}, author = {{King, Ben C. and Blom, Anna M.}}, issn = {{0014-2980}}, keywords = {{Immunometabolism; Inflammation; Intracellular complement}}, language = {{eng}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Immunology}}, title = {{Intracellular complement and immunometabolism : The advantages of compartmentalization}}, url = {{http://dx.doi.org/10.1002/eji.202350813}}, doi = {{10.1002/eji.202350813}}, year = {{2024}}, }