Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Deregulation of protein phosphatase expression in acute myeloid leukemia

Kabir, Nuzhat N. ; Rönnstrand, Lars LU orcid and Kazi, Julhash U. LU orcid (2013) In Medical Oncology 30(2).
Abstract
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in... (More)
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dual specificity, Protein serine/threonine phosphatase, phosphatase, Protein tyrosine, Protein phosphatase, Acute myeloid leukemia, AML
in
Medical Oncology
volume
30
issue
2
publisher
Humana Press
external identifiers
  • wos:000319450400026
  • scopus:84874088035
  • pmid:23440723
ISSN
1559-131X
DOI
10.1007/s12032-013-0517-8
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
id
9a2c8ce8-c876-4896-955d-481ae84e03a8 (old id 3990389)
date added to LUP
2016-04-01 14:41:20
date last changed
2025-04-04 14:17:01
@article{9a2c8ce8-c876-4896-955d-481ae84e03a8,
  abstract     = {{Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.}},
  author       = {{Kabir, Nuzhat N. and Rönnstrand, Lars and Kazi, Julhash U.}},
  issn         = {{1559-131X}},
  keywords     = {{Dual specificity; Protein serine/threonine phosphatase; phosphatase; Protein tyrosine; Protein phosphatase; Acute myeloid leukemia; AML}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Humana Press}},
  series       = {{Medical Oncology}},
  title        = {{Deregulation of protein phosphatase expression in acute myeloid leukemia}},
  url          = {{https://lup.lub.lu.se/search/files/4109275/4316400.pdf}},
  doi          = {{10.1007/s12032-013-0517-8}},
  volume       = {{30}},
  year         = {{2013}},
}