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Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis

Marini, Sandro ; Hansen, Björn LU ; Norrving, Bo LU ; Lindgren, Arne LU and Anderson, Christopher D. (2019) In JAMA Neurology
Abstract
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ϵ4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a... (More)
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ϵ4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures: Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results: In total, 13124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ϵ2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P (Less)
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Contribution to journal
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published
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JAMA Neurology
publisher
American Medical Association
external identifiers
  • scopus:85061337779
  • pmid:30726504
ISSN
2168-6157
DOI
10.1001/jamaneurol.2018.4519
language
English
LU publication?
yes
additional info
Export Date: 22 February 2019
id
3e726831-de92-460a-bb66-55b3cd7db704
date added to LUP
2019-02-22 13:16:04
date last changed
2022-04-25 21:21:15
@article{3e726831-de92-460a-bb66-55b3cd7db704,
  abstract     = {{Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ϵ4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures: Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results: In total, 13124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ϵ2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P}},
  author       = {{Marini, Sandro and Hansen, Björn and Norrving, Bo and Lindgren, Arne and Anderson, Christopher D.}},
  issn         = {{2168-6157}},
  language     = {{eng}},
  publisher    = {{American Medical Association}},
  series       = {{JAMA Neurology}},
  title        = {{Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis}},
  url          = {{http://dx.doi.org/10.1001/jamaneurol.2018.4519}},
  doi          = {{10.1001/jamaneurol.2018.4519}},
  year         = {{2019}},
}