Number of spikes in climbing fibers determines the direction of cerebellar learning.
(2013) In The Journal of Neuroscience 33(33). p.13436-13440- Abstract
- Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4005689
- author
- Rasmussen, Anders LU ; Jirenhed, Dan-Anders LU ; Zucca, Riccardo ; Johansson, Fredrik LU ; Svensson, Pär LU and Hesslow, Germund LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Neuroscience
- volume
- 33
- issue
- 33
- pages
- 13436 - 13440
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000323155700018
- pmid:23946401
- scopus:84881503310
- pmid:23946401
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.1527-13.2013
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 4eb6e75d-8caf-4750-8b16-6d949f8323a1 (old id 4005689)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23946401?dopt=Abstract
- date added to LUP
- 2016-04-01 11:02:16
- date last changed
- 2023-08-31 17:13:47
@article{4eb6e75d-8caf-4750-8b16-6d949f8323a1, abstract = {{Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.}}, author = {{Rasmussen, Anders and Jirenhed, Dan-Anders and Zucca, Riccardo and Johansson, Fredrik and Svensson, Pär and Hesslow, Germund}}, issn = {{1529-2401}}, language = {{eng}}, number = {{33}}, pages = {{13436--13440}}, publisher = {{Society for Neuroscience}}, series = {{The Journal of Neuroscience}}, title = {{Number of spikes in climbing fibers determines the direction of cerebellar learning.}}, url = {{https://lup.lub.lu.se/search/files/2330556/4286411.pdf}}, doi = {{10.1523/JNEUROSCI.1527-13.2013}}, volume = {{33}}, year = {{2013}}, }