Mapping the intracellular fraction of water by varying the gradient pulse length in q-space diffusion MRI
Malmborg, Carin LU ; Sjöbeck, Martin LU ; Brockstedt, Sara LU ; Englund, Elisabet LU
; Söderman, Olle
LU
and Topgaard, Daniel
LU
(2006)
In Journal of Magnetic Resonance
180(2).
p.280-285
- Abstract
- Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined... (More)
- Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined free and restricted diffusion behavior. Time-resolved diffusion MRI experiments are used to map the spatial distribution of the intracellular fraction in a yeast cell suspension during sedimentation, and observe the disappearance of this fraction after a heat treatment. (c) 2006 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/408299
- author
- Malmborg, Carin
LU
; Sjöbeck, Martin
LU
; Brockstedt, Sara
LU
; Englund, Elisabet
LU
; Söderman, Olle
LU
and Topgaard, Daniel
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- imaging, tissue, PGSE, pulsed field gradient, SGP
- in
- Journal of Magnetic Resonance
- volume
- 180
- issue
- 2
- pages
- 280 - 285
- publisher
- Academic Press
- external identifiers
-
- pmid:16571376
- wos:000237875300015
- scopus:33646353917
- ISSN
- 1096-0856
- DOI
- 10.1016/j.jmr.2006.03.005
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Radiation Physics, Lund (013034000), Physical Chemistry 1 (S) (011001006), Department of Clinical Sciences, Lund (013230000)
- id
- 33275519-dfbb-4a2c-bdb2-207cb6d543c1 (old id 408299)
- date added to LUP
- 2016-04-01 15:22:19
- date last changed
- 2022-01-28 04:59:45
@article{33275519-dfbb-4a2c-bdb2-207cb6d543c1,
abstract = {{Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined free and restricted diffusion behavior. Time-resolved diffusion MRI experiments are used to map the spatial distribution of the intracellular fraction in a yeast cell suspension during sedimentation, and observe the disappearance of this fraction after a heat treatment. (c) 2006 Elsevier Inc. All rights reserved.}},
author = {{Malmborg, Carin and Sjöbeck, Martin and Brockstedt, Sara and Englund, Elisabet and Söderman, Olle and Topgaard, Daniel}},
issn = {{1096-0856}},
keywords = {{imaging; tissue; PGSE; pulsed field gradient; SGP}},
language = {{eng}},
number = {{2}},
pages = {{280--285}},
publisher = {{Academic Press}},
series = {{Journal of Magnetic Resonance}},
title = {{Mapping the intracellular fraction of water by varying the gradient pulse length in q-space diffusion MRI}},
url = {{http://dx.doi.org/10.1016/j.jmr.2006.03.005}},
doi = {{10.1016/j.jmr.2006.03.005}},
volume = {{180}},
year = {{2006}},
}