The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells
(2013) In Cell Reports 4(4). p.642-648- Abstract
- Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function. Using CD9 as a tool to subdivide hematopoietic stem-cell-containing populations, we provide evidence for heterogeneity at the cellular, functional, and molecular levels.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172665
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Reports
- volume
- 4
- issue
- 4
- pages
- 642 - 648
- publisher
- Cell Press
- external identifiers
-
- wos:000324285700004
- scopus:84883264782
- pmid:23954783
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2013.07.020
- language
- English
- LU publication?
- yes
- id
- 861cc339-9cf1-486d-993e-55b166ec633c (old id 4172665)
- date added to LUP
- 2016-04-01 13:02:28
- date last changed
- 2022-03-29 05:12:05
@article{861cc339-9cf1-486d-993e-55b166ec633c, abstract = {{Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function. Using CD9 as a tool to subdivide hematopoietic stem-cell-containing populations, we provide evidence for heterogeneity at the cellular, functional, and molecular levels.}}, author = {{Karlsson, Göran and Rörby, Emma and Pina, Cristina and Soneji, Shamit and Reckzeh, Kristian and Miharada, Kenichi and Karlsson, Christine and Guo, Yanping and Fugazza, Cristina and Gupta, Rajeev and Martens, Joost H. A. and Stunnenberg, Hendrik G. and Karlsson, Stefan and Enver, Tariq}}, issn = {{2211-1247}}, language = {{eng}}, number = {{4}}, pages = {{642--648}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells}}, url = {{https://lup.lub.lu.se/search/files/3123489/4431948.pdf}}, doi = {{10.1016/j.celrep.2013.07.020}}, volume = {{4}}, year = {{2013}}, }