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Trend shifts in age-specific incidence for in situ and invasive cutaneous melanoma in sweden

Eriksson, Hanna ; Nielsen, Kari LU orcid ; Vassilaki, Ismini ; Lapins, Jan ; Mikiver, Rasmus ; Lyth, Johan and Isaksson, Karolin LU (2021) In Cancers 13(11).
Abstract

Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350 in situ CM; 59,932 CM). Results: The AAPC of CM for women was 4.5 (4.1–5.0; p < 0.001) for the period 1997–2018. For men, the APCC was 4.2 (3.0–5.4; p < 0.001), with a significantly higher annual percentage change (APC) for the period 2000–2018 (5.0; 4.6–5.4; p < 0.001) compared to 1997–1999. An increasing annual incidence of CM ≤ 0.6... (More)

Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350 in situ CM; 59,932 CM). Results: The AAPC of CM for women was 4.5 (4.1–5.0; p < 0.001) for the period 1997–2018. For men, the APCC was 4.2 (3.0–5.4; p < 0.001), with a significantly higher annual percentage change (APC) for the period 2000–2018 (5.0; 4.6–5.4; p < 0.001) compared to 1997–1999. An increasing annual incidence of CM ≤ 0.6 mm and 0.7 mm Breslow tumour thickness was found for men with a significant incidence shift for the period 2006–2015, respectively. Similarly for women, with a significantly higher APC for CM ≤ 0.6 mm from 2005. The incidence of intermediate thick CM (2.1–4.0 mm) has not increased since 2011. The incidence of CM > 4.0 mm has been increasing among both sexes, with a significantly lower APC among women from 2005. Conclusions: The incidence of in situ and low-risk CM ≤ 1.0 mm in tumour thickness has been rising among both sexes since the 2000s.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age-specific incidence, Average annual percentage change, Cutaneous melanoma, Joinpoint, Trend shifts
in
Cancers
volume
13
issue
11
article number
2838
publisher
MDPI AG
external identifiers
  • pmid:34200396
  • scopus:85107267015
ISSN
2072-6694
DOI
10.3390/cancers13112838
language
English
LU publication?
yes
additional info
Funding Information: The Swedish Cancer Society (190278Fk01H, 210406 JCIA), the Cancer Research Foundations of Radiumhemmet (181083), the Swedish Medical Society (SLS-934511, SLS-961466), the Swedish Society for Medical Research (2017), KI Funds (FS-2020:0007), Hudfonden (4-1880/2020), the Sigurd and Elsa Golje Memorial Fund (LA-2020-0148), Folkfonden (2020), Castenb?ck Fund (2020. K.I.: S. Paulsson Fund, M. Paulsson Fund K.N.: Hudfonden (2020), S.R. Gorthon foundation (2020), Krapperup foundation (0029-2020), FOU Region Skane (REGSKANE-815731) and ALF Lund University (2018?2020). Funding Information: Funding: H.E.: The Swedish Cancer Society (190278Fk01H, 210406 JCIA), the Cancer Research Foundations of Radiumhemmet (181083), the Swedish Medical Society (SLS-934511, SLS-961466), the Swedish Society for Medical Research (2017), KI Funds (FS-2020:0007), Hudfonden (4-1880/2020), the Sigurd and Elsa Golje Memorial Fund (LA-2020-0148), Folkfonden (2020), Castenbäck Fund (2020. K.I.: S. Paulsson Fund, M. Paulsson Fund K.N.: Hudfonden (2020), S.R. Gorthon foundation (2020), Krapperup foundation (0029-2020), FOU Region Skane (REGSKANE-815731) and ALF Lund University (2018–2020). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
42033e0c-0f75-4d05-8e9a-acb8e4c817f1
date added to LUP
2021-06-16 12:38:01
date last changed
2024-04-20 07:36:22
@article{42033e0c-0f75-4d05-8e9a-acb8e4c817f1,
  abstract     = {{<p>Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350 in situ CM; 59,932 CM). Results: The AAPC of CM for women was 4.5 (4.1–5.0; p &lt; 0.001) for the period 1997–2018. For men, the APCC was 4.2 (3.0–5.4; p &lt; 0.001), with a significantly higher annual percentage change (APC) for the period 2000–2018 (5.0; 4.6–5.4; p &lt; 0.001) compared to 1997–1999. An increasing annual incidence of CM ≤ 0.6 mm and 0.7 mm Breslow tumour thickness was found for men with a significant incidence shift for the period 2006–2015, respectively. Similarly for women, with a significantly higher APC for CM ≤ 0.6 mm from 2005. The incidence of intermediate thick CM (2.1–4.0 mm) has not increased since 2011. The incidence of CM &gt; 4.0 mm has been increasing among both sexes, with a significantly lower APC among women from 2005. Conclusions: The incidence of in situ and low-risk CM ≤ 1.0 mm in tumour thickness has been rising among both sexes since the 2000s.</p>}},
  author       = {{Eriksson, Hanna and Nielsen, Kari and Vassilaki, Ismini and Lapins, Jan and Mikiver, Rasmus and Lyth, Johan and Isaksson, Karolin}},
  issn         = {{2072-6694}},
  keywords     = {{Age-specific incidence; Average annual percentage change; Cutaneous melanoma; Joinpoint; Trend shifts}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Trend shifts in age-specific incidence for in situ and invasive cutaneous melanoma in sweden}},
  url          = {{http://dx.doi.org/10.3390/cancers13112838}},
  doi          = {{10.3390/cancers13112838}},
  volume       = {{13}},
  year         = {{2021}},
}