Identification of tumor margins using diffuse reflectance spectroscopy with an extended-wavelength spectrum in a porcine model
(2018) In Skin Research and Technology 24(4). p.667-671- Abstract
OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.
MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined... (More)
OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.
MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.
RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.
CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.
(Less)
- author
- Dahlstrand, U LU ; Sheikh, R LU ; Nguyen, C D LU ; Hult, J LU ; Reistad, N LU and Malmsjö, M LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Skin Research and Technology
- volume
- 24
- issue
- 4
- pages
- 5 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85054294356
- pmid:29774600
- ISSN
- 0909-752X
- DOI
- 10.1111/srt.12583
- language
- English
- LU publication?
- yes
- id
- 42b93ce3-0a41-4cbf-9ae0-cabff80c9afe
- date added to LUP
- 2018-05-22 21:18:47
- date last changed
- 2024-07-08 14:16:30
@article{42b93ce3-0a41-4cbf-9ae0-cabff80c9afe, abstract = {{<p>OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.</p><p>MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.</p><p>RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.</p><p>CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.</p>}}, author = {{Dahlstrand, U and Sheikh, R and Nguyen, C D and Hult, J and Reistad, N and Malmsjö, M}}, issn = {{0909-752X}}, keywords = {{Journal Article}}, language = {{eng}}, number = {{4}}, pages = {{667--671}}, publisher = {{Wiley-Blackwell}}, series = {{Skin Research and Technology}}, title = {{Identification of tumor margins using diffuse reflectance spectroscopy with an extended-wavelength spectrum in a porcine model}}, url = {{http://dx.doi.org/10.1111/srt.12583}}, doi = {{10.1111/srt.12583}}, volume = {{24}}, year = {{2018}}, }