Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer
Berntsson, Jonna LU ; Lundgren, Sebastian LU ; Nodin, Björn LU ; Uhlen, Mathias ; Gaber, Alexander LU and Jirström, Karin LU
(2014)
In Journal of Ovarian Research
7.
- Abstract
- Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expression in EOC. Methods: After an initial screening in the Human Protein Atlas portal, a validated antibody was selected for extended analysis of immunohistochemical PIGR expression in tissue microarrays with tumours from 154 incident cases of EOC from two pooled prospective population-based cohorts. Subsets of corresponding benign-appearing... (More)
- Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expression in EOC. Methods: After an initial screening in the Human Protein Atlas portal, a validated antibody was selected for extended analysis of immunohistochemical PIGR expression in tissue microarrays with tumours from 154 incident cases of EOC from two pooled prospective population-based cohorts. Subsets of corresponding benign-appearing fallopian tubes (n = 38) and omental metastases (n = 33) were also analysed. Kaplan-Meier analysis and Cox regression analysis were applied to examine the impact of PIGR expression on overall survival (OS) and ovarian cancer-specific survival (OCSS). Results: PIGR expression was significantly higher in fallopian tubes compared to primary tumours and metastases (p < 0.001) and lower in carcinoma of the serous subtype compared to other carcinomas (p < 0.001). PIGR expression was significantly associated with lower grade (p = 0.001), mucinous histological subtype (p = 0.002), positive progesterone receptor expression (p = 0.009) and negative or low Ki-67 expression (p = 0.003). Kaplan-Meier analysis revealed a significantly improved OS (p = 0.013) and OCSS (p = 0.009) for patients with tumours displaying high expression of PIGR. These associations were confirmed in unadjusted Cox regression analysis (HR = 0.48; 95% CI 0.26-0.87; p = 0.015 for OS and HR = 0.43, 95% CI 0.22-0.82; p = 0.011 for OCSS) but did not remain significant after adjustment for age, grade and clinical stage. Conclusions: This study provides a first demonstration of PIGR expression in human fallopian tubes, primary EOC tumours and metastases. High tumour-specific expression of PIGR was found to be associated with a favourable prognosis in unadjusted, but not in adjusted, analysis. These findings are novel and merit further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4411147
- author
- Berntsson, Jonna
LU
; Lundgren, Sebastian
LU
; Nodin, Björn
LU
; Uhlen, Mathias
; Gaber, Alexander
LU
and Jirström, Karin
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Polymeric immunoglobulin receptor, Fallopian tubes, Ovarian cancer, Prognosis
- in
- Journal of Ovarian Research
- volume
- 7
- article number
- 26
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000333112700001
- scopus:84896718105
- pmid:24568264
- ISSN
- 1757-2215
- DOI
- 10.1186/1757-2215-7-26
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- b0892308-7b32-483f-bad5-d9bf8a79d4f5 (old id 4411147)
- date added to LUP
- 2016-04-01 14:10:02
- date last changed
- 2024-01-29 02:53:37
@article{b0892308-7b32-483f-bad5-d9bf8a79d4f5,
abstract = {{Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expression in EOC. Methods: After an initial screening in the Human Protein Atlas portal, a validated antibody was selected for extended analysis of immunohistochemical PIGR expression in tissue microarrays with tumours from 154 incident cases of EOC from two pooled prospective population-based cohorts. Subsets of corresponding benign-appearing fallopian tubes (n = 38) and omental metastases (n = 33) were also analysed. Kaplan-Meier analysis and Cox regression analysis were applied to examine the impact of PIGR expression on overall survival (OS) and ovarian cancer-specific survival (OCSS). Results: PIGR expression was significantly higher in fallopian tubes compared to primary tumours and metastases (p < 0.001) and lower in carcinoma of the serous subtype compared to other carcinomas (p < 0.001). PIGR expression was significantly associated with lower grade (p = 0.001), mucinous histological subtype (p = 0.002), positive progesterone receptor expression (p = 0.009) and negative or low Ki-67 expression (p = 0.003). Kaplan-Meier analysis revealed a significantly improved OS (p = 0.013) and OCSS (p = 0.009) for patients with tumours displaying high expression of PIGR. These associations were confirmed in unadjusted Cox regression analysis (HR = 0.48; 95% CI 0.26-0.87; p = 0.015 for OS and HR = 0.43, 95% CI 0.22-0.82; p = 0.011 for OCSS) but did not remain significant after adjustment for age, grade and clinical stage. Conclusions: This study provides a first demonstration of PIGR expression in human fallopian tubes, primary EOC tumours and metastases. High tumour-specific expression of PIGR was found to be associated with a favourable prognosis in unadjusted, but not in adjusted, analysis. These findings are novel and merit further investigation.}},
author = {{Berntsson, Jonna and Lundgren, Sebastian and Nodin, Björn and Uhlen, Mathias and Gaber, Alexander and Jirström, Karin}},
issn = {{1757-2215}},
keywords = {{Polymeric immunoglobulin receptor; Fallopian tubes; Ovarian cancer; Prognosis}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Journal of Ovarian Research}},
title = {{Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer}},
url = {{https://lup.lub.lu.se/search/files/3821715/4777573}},
doi = {{10.1186/1757-2215-7-26}},
volume = {{7}},
year = {{2014}},
}