Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography.
(2014) In BMC Gastroenterology 14(1).- Abstract
- Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients... (More)
- Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients with various hepatobiliary diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4615475
- author
- Duan, Rui-Dong LU ; Hindorf, Ulf LU ; Cheng, Yajun LU ; Bergenzaun, Per LU ; Hall, Mats LU ; Hertervig, Erik LU and Nilsson, Åke LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Gastroenterology
- volume
- 14
- issue
- 1
- article number
- 138
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:25100243
- wos:000340632700002
- scopus:84906837288
- pmid:25100243
- ISSN
- 1471-230X
- DOI
- 10.1186/1471-230X-14-138
- language
- English
- LU publication?
- yes
- id
- 69588fae-f49a-411e-858a-b6a48bc39007 (old id 4615475)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25100243?dopt=Abstract
- date added to LUP
- 2016-04-01 13:36:46
- date last changed
- 2024-02-25 01:13:32
@article{69588fae-f49a-411e-858a-b6a48bc39007,
abstract = {{Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients with various hepatobiliary diseases.}},
author = {{Duan, Rui-Dong and Hindorf, Ulf and Cheng, Yajun and Bergenzaun, Per and Hall, Mats and Hertervig, Erik and Nilsson, Åke}},
issn = {{1471-230X}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Gastroenterology}},
title = {{Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography.}},
url = {{https://lup.lub.lu.se/search/files/3477588/7865019}},
doi = {{10.1186/1471-230X-14-138}},
volume = {{14}},
year = {{2014}},
}