Treatment with betablockers is associated with higher grey-scale median in carotid plaques
Asciutto, Giuseppe LU ; Dias, Nuno LU
; Persson, Ana
LU
; Nilsson, Jan
LU
and Goncalves, Isabel
LU
(2014)
In BMC Cardiovascular Disorders
14.
- Abstract
- Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the carotid plaques of 350 patients who underwent carotid endarterectomy (CEA) for asymptomatic (n = 113) or symptomatic (n = 237) carotid disease was measured. Patients were divided in two groups based on the absence/presence of an on-going long-term (i.e. at least 6 months) oral treatment with betablockers at the time of CEA. Results: The prevalence... (More)
- Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the carotid plaques of 350 patients who underwent carotid endarterectomy (CEA) for asymptomatic (n = 113) or symptomatic (n = 237) carotid disease was measured. Patients were divided in two groups based on the absence/presence of an on-going long-term (i.e. at least 6 months) oral treatment with betablockers at the time of CEA. Results: The prevalence and type of preoperative neurological symptoms were similar in the two groups. Patients with betablockers had more frequently arterial hypertension (P < .0001), diabetes (P = .035) and a higher BMI (P = .0004), while patients without betablockers were most frequently smokers (P = .017). Patients with betablockers revealed to have higher GSM (37.79 +/- 25 vs 32.61 +/- 23.50 P = .036). Echogenic plaques (i.e. with GSM > 30) showed to be more frequent in patients with betablockers also after correction for age, gender, the occurrence of preoperative symptoms, diabetes, hypertension, smoking and statins use (P = .024). Conclusions: These results suggest the use of standardized ultrasound techniques as an important tool in evaluating the effect of anti-atherosclerotic medications and underline the need of. further prospective randomized studies on larger patient cohorts in order to confirm these results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4648961
- author
- Asciutto, Giuseppe
LU
; Dias, Nuno
LU
; Persson, Ana
LU
; Nilsson, Jan
LU
and Goncalves, Isabel
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Betablockers, Grey-scale median, Carotid artery, Carotid plaque
- in
- BMC Cardiovascular Disorders
- volume
- 14
- article number
- 111
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000341033600001
- pmid:25175336
- scopus:84906923087
- pmid:25175336
- ISSN
- 1471-2261
- DOI
- 10.1186/1471-2261-14-111
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Cardiovascular Research Unit (013242110), Emergency medicine/Medicine/Surgery (013240200)
- id
- e91a866c-c0de-4935-8449-77a57526786a (old id 4648961)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25175336?dopt=Abstract
- date added to LUP
- 2016-04-01 14:40:54
- date last changed
- 2022-02-07 11:38:49
@article{e91a866c-c0de-4935-8449-77a57526786a,
abstract = {{Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the carotid plaques of 350 patients who underwent carotid endarterectomy (CEA) for asymptomatic (n = 113) or symptomatic (n = 237) carotid disease was measured. Patients were divided in two groups based on the absence/presence of an on-going long-term (i.e. at least 6 months) oral treatment with betablockers at the time of CEA. Results: The prevalence and type of preoperative neurological symptoms were similar in the two groups. Patients with betablockers had more frequently arterial hypertension (P < .0001), diabetes (P = .035) and a higher BMI (P = .0004), while patients without betablockers were most frequently smokers (P = .017). Patients with betablockers revealed to have higher GSM (37.79 +/- 25 vs 32.61 +/- 23.50 P = .036). Echogenic plaques (i.e. with GSM > 30) showed to be more frequent in patients with betablockers also after correction for age, gender, the occurrence of preoperative symptoms, diabetes, hypertension, smoking and statins use (P = .024). Conclusions: These results suggest the use of standardized ultrasound techniques as an important tool in evaluating the effect of anti-atherosclerotic medications and underline the need of. further prospective randomized studies on larger patient cohorts in order to confirm these results.}},
author = {{Asciutto, Giuseppe and Dias, Nuno and Persson, Ana and Nilsson, Jan and Goncalves, Isabel}},
issn = {{1471-2261}},
keywords = {{Betablockers; Grey-scale median; Carotid artery; Carotid plaque}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cardiovascular Disorders}},
title = {{Treatment with betablockers is associated with higher grey-scale median in carotid plaques}},
url = {{https://lup.lub.lu.se/search/files/4104917/5277018}},
doi = {{10.1186/1471-2261-14-111}},
volume = {{14}},
year = {{2014}},
}