Acral Melanoma Incidence and Survival Trends in 1990–2020: A Nationwide, Population-based Study
Helkkula, Teo LU ; Christensen, Gustav LU ; Mikiver, Rasmus ; Ingvar, Åsa LU
; Isaksson, Karolin
LU
and Nielsen, Kari
LU
(2024)
In Acta Dermato-Venereologica
104.
- Abstract
- Acral melanoma is a clinical subtype of melanoma with high mortality, on which research is limited in scope. This study aimed to assess incidence trends and melanoma-specific survival rates for acral melanoma in the Swedish population from 1990 to 2020.This cross-sectional study included patients with an acral melanoma diagnosis from 1990 to 2020 from the nationwide, population-based Swedish Melanoma Registry. Analyses on acral melanoma melanoma-specific survival rates were adjusted for age, sex, histopathological subtype, and tumour thickness. Clinicopathological features and melanoma-specific survival rates were compared between diagnostic periods: 1990–1999, 2000–2009, and 2010–2020, respectively. Changes in standardized incidence rates... (More)
- Acral melanoma is a clinical subtype of melanoma with high mortality, on which research is limited in scope. This study aimed to assess incidence trends and melanoma-specific survival rates for acral melanoma in the Swedish population from 1990 to 2020.This cross-sectional study included patients with an acral melanoma diagnosis from 1990 to 2020 from the nationwide, population-based Swedish Melanoma Registry. Analyses on acral melanoma melanoma-specific survival rates were adjusted for age, sex, histopathological subtype, and tumour thickness. Clinicopathological features and melanoma-specific survival rates were compared between diagnostic periods: 1990–1999, 2000–2009, and 2010–2020, respectively. Changes in standardized incidence rates in 1996–2020 were evaluated separately for males and females. In total, 1,000 acral melanomas in 999 patients were included in the study. No significant yearly change in standardized incidence rates for either males or females was observed, even though the absolute number of cases increased. Factors such as male sex, age ≥ 70 years, and Breslow thickness > 1.0 were independently linked to lower melanoma-specific survival. The 5-year melanoma-specific survival across the studied period ranged from 75.8% to 77.9% for females, and from 62.4% to 71.7% for males. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4732c567-8078-4a9b-9cec-a71e36a95a04
- author
- Helkkula, Teo
LU
; Christensen, Gustav
LU
; Mikiver, Rasmus
; Ingvar, Åsa
LU
; Isaksson, Karolin
LU
and Nielsen, Kari
LU
- organization
- publishing date
- 2024-08-14
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Incidence, Melanoma, Survival Rate
- in
- Acta Dermato-Venereologica
- volume
- 104
- publisher
- Medical Journals Limited
- ISSN
- 1651-2057
- DOI
- 10.2340/actadv.v104.40242
- language
- English
- LU publication?
- yes
- id
- 4732c567-8078-4a9b-9cec-a71e36a95a04
- date added to LUP
- 2024-08-14 14:15:53
- date last changed
- 2024-08-14 15:10:18
@article{4732c567-8078-4a9b-9cec-a71e36a95a04,
abstract = {{Acral melanoma is a clinical subtype of melanoma with high mortality, on which research is limited in scope. This study aimed to assess incidence trends and melanoma-specific survival rates for acral melanoma in the Swedish population from 1990 to 2020.This cross-sectional study included patients with an acral melanoma diagnosis from 1990 to 2020 from the nationwide, population-based Swedish Melanoma Registry. Analyses on acral melanoma melanoma-specific survival rates were adjusted for age, sex, histopathological subtype, and tumour thickness. Clinicopathological features and melanoma-specific survival rates were compared between diagnostic periods: 1990–1999, 2000–2009, and 2010–2020, respectively. Changes in standardized incidence rates in 1996–2020 were evaluated separately for males and females. In total, 1,000 acral melanomas in 999 patients were included in the study. No significant yearly change in standardized incidence rates for either males or females was observed, even though the absolute number of cases increased. Factors such as male sex, age ≥ 70 years, and Breslow thickness > 1.0 were independently linked to lower melanoma-specific survival. The 5-year melanoma-specific survival across the studied period ranged from 75.8% to 77.9% for females, and from 62.4% to 71.7% for males.}},
author = {{Helkkula, Teo and Christensen, Gustav and Mikiver, Rasmus and Ingvar, Åsa and Isaksson, Karolin and Nielsen, Kari}},
issn = {{1651-2057}},
keywords = {{Incidence, Melanoma, Survival Rate}},
language = {{eng}},
month = {{08}},
publisher = {{Medical Journals Limited}},
series = {{Acta Dermato-Venereologica}},
title = {{Acral Melanoma Incidence and Survival Trends in 1990–2020: A Nationwide, Population-based Study}},
url = {{http://dx.doi.org/10.2340/actadv.v104.40242}},
doi = {{10.2340/actadv.v104.40242}},
volume = {{104}},
year = {{2024}},
}