The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus.
(2014) In Drug Target Insights 8. p.45-50- Abstract
- Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records... (More)
- Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records were scrutinized. Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4913219
- author
- Roth, Bodil LU ; Berntorp, Kerstin LU and Ohlsson, Bodil LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Target Insights
- volume
- 8
- pages
- 45 - 50
- publisher
- Libertas Academica
- external identifiers
-
- pmid:25452692
- scopus:84924853022
- pmid:25452692
- ISSN
- 1177-3928
- DOI
- 10.4137/DTI.S19352
- language
- English
- LU publication?
- yes
- id
- fefc49a9-3acd-4320-a1ce-b9c831815d49 (old id 4913219)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25452692?dopt=Abstract
- date added to LUP
- 2016-04-01 14:48:25
- date last changed
- 2024-03-27 23:41:47
@article{fefc49a9-3acd-4320-a1ce-b9c831815d49,
abstract = {{Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records were scrutinized. Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls.}},
author = {{Roth, Bodil and Berntorp, Kerstin and Ohlsson, Bodil}},
issn = {{1177-3928}},
language = {{eng}},
pages = {{45--50}},
publisher = {{Libertas Academica}},
series = {{Drug Target Insights}},
title = {{The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus.}},
url = {{https://lup.lub.lu.se/search/files/4176222/7766109.pdf}},
doi = {{10.4137/DTI.S19352}},
volume = {{8}},
year = {{2014}},
}