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Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction : What Do We Know?

Bisaccia, Giandomenico ; Ricci, Fabrizio LU ; Recce, Vittoria ; Serio, Antonio ; Iannetti, Giovanni ; Chahal, Anwar A ; Ståhlberg, Marcus ; Khanji, Mohammed Yunus ; Fedorowski, Artur LU orcid and Gallina, Sabina (2021) In Journal of cardiovascular development and disease 8(11). p.1-15
Abstract

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the... (More)

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of cardiovascular development and disease
volume
8
issue
11
article number
156
pages
1 - 15
publisher
MDPI AG
external identifiers
  • scopus:85119669555
  • pmid:34821709
ISSN
2308-3425
DOI
10.3390/jcdd8110156
language
English
LU publication?
yes
id
4e3d67c2-dfb3-413b-8007-4e8ead88228e
date added to LUP
2021-11-26 15:39:07
date last changed
2024-08-11 02:24:44
@article{4e3d67c2-dfb3-413b-8007-4e8ead88228e,
  abstract     = {{<p>Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system. Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia. In this review, we report on the epidemiology of PASC, discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system, and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC-associated dysautonomia.</p>}},
  author       = {{Bisaccia, Giandomenico and Ricci, Fabrizio and Recce, Vittoria and Serio, Antonio and Iannetti, Giovanni and Chahal, Anwar A and Ståhlberg, Marcus and Khanji, Mohammed Yunus and Fedorowski, Artur and Gallina, Sabina}},
  issn         = {{2308-3425}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1--15}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of cardiovascular development and disease}},
  title        = {{Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction : What Do We Know?}},
  url          = {{http://dx.doi.org/10.3390/jcdd8110156}},
  doi          = {{10.3390/jcdd8110156}},
  volume       = {{8}},
  year         = {{2021}},
}