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Association between self-reported alcohol consumption and diastolic dysfunction : a cross-sectional study

Daka, Bledar ; Bennet, Louise LU orcid ; Råstam, Lennart LU ; Hellgren, Margareta I ; Li, Ying ; Magnusson, Martin LU orcid and Lindblad, Ulf LU (2023) In BMJ Open 13(10).
Abstract

BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear.Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques.

DESIGN: Cross-sectional observational study in community-based population.

SETTINGS, PARTICIPANTS AND METHODS: Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European... (More)

BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear.Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques.

DESIGN: Cross-sectional observational study in community-based population.

SETTINGS, PARTICIPANTS AND METHODS: Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European Society of Cardiology criteria, excluding subjects with ejection fraction <45%, self-reported history of heart failure or atrial fibrillation on ECG. Self-reported alcohol intake using a validated questionnaire was categorised as
no intake, low and medium-high intake.

RESULTS: In total, 500 men and 538 women (mean age 55.4±13) were successfully examined. Diastolic dysfunction was identified in 16% (79/500) of the men and 13% (58/538) of the women. The multivariable adjusted model revealed a strong and independent association between alcohol intake and diastolic dysfunction. In fact, using no alcohol intake as reference, diastolic dysfunction was independently associated with alcohol consumption in a dose-dependent fashion;
low consumption, OR 2.3 (95% CI 1.3 to 4.0) and
medium-high consumption OR 3.1 (95% CI 1.6 to 6.2), respectively.

CONCLUSION: There was a significant association between alcohol consumption and diastolic dysfunction starting already at low levels that was supported by a dose-dependent pattern. These results need confirmatory studies and are important in public health policies.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMJ Open
volume
13
issue
10
article number
e069937
publisher
BMJ Publishing Group
external identifiers
  • scopus:85174642289
  • pmid:37821143
ISSN
2044-6055
DOI
10.1136/bmjopen-2022-069937
project
Nationwide research collaboration in family medicine and type 2 diabetes - Swedish Primary Care Diabetes (SPACE)
language
English
LU publication?
yes
additional info
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
id
50530a00-8e2c-4323-9a83-a95ced473d40
date added to LUP
2023-10-15 08:28:30
date last changed
2025-02-03 07:49:08
@article{50530a00-8e2c-4323-9a83-a95ced473d40,
  abstract     = {{<p>BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear.Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques.</p><p>DESIGN: Cross-sectional observational study in community-based population.</p><p>SETTINGS, PARTICIPANTS AND METHODS: Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European Society of Cardiology criteria, excluding subjects with ejection fraction &lt;45%, self-reported history of heart failure or atrial fibrillation on ECG. Self-reported alcohol intake using a validated questionnaire was categorised as <br>
 no intake, low and medium-high intake.<br>
 </p><p>RESULTS: In total, 500 men and 538 women (mean age 55.4±13) were successfully examined. Diastolic dysfunction was identified in 16% (79/500) of the men and 13% (58/538) of the women. The multivariable adjusted model revealed a strong and independent association between alcohol intake and diastolic dysfunction. In fact, using no alcohol intake as reference, diastolic dysfunction was independently associated with alcohol consumption in a dose-dependent fashion;<br>
 low consumption, OR 2.3 (95% CI 1.3 to 4.0) and <br>
 medium-high consumption OR 3.1 (95% CI 1.6 to 6.2), respectively.<br>
 </p><p>CONCLUSION: There was a significant association between alcohol consumption and diastolic dysfunction starting already at low levels that was supported by a dose-dependent pattern. These results need confirmatory studies and are important in public health policies.</p>}},
  author       = {{Daka, Bledar and Bennet, Louise and Råstam, Lennart and Hellgren, Margareta I and Li, Ying and Magnusson, Martin and Lindblad, Ulf}},
  issn         = {{2044-6055}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Association between self-reported alcohol consumption and diastolic dysfunction : a cross-sectional study}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2022-069937}},
  doi          = {{10.1136/bmjopen-2022-069937}},
  volume       = {{13}},
  year         = {{2023}},
}