Arsenic trioxide and neuroblastoma cytotoxicity.
(2007) In Journal of Bioenergetics and Biomembranes 39(1). p.35-41- Abstract
- The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the children with neuroblastoma have an aggressive form, there is a compelling demand for new treatment strategies. Arsenic trioxide has the capacity to kill multidrug-resistant neuro-blastoma cells in vitro and in vivo and the drug is currently being evaluated in clinical trials. In this report we discuss the background to the use of arsenic trioxide in... (More)
- The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the children with neuroblastoma have an aggressive form, there is a compelling demand for new treatment strategies. Arsenic trioxide has the capacity to kill multidrug-resistant neuro-blastoma cells in vitro and in vivo and the drug is currently being evaluated in clinical trials. In this report we discuss the background to the use of arsenic trioxide in cancer therapy and the currently known mechanisms by which arsenic trioxide kills human neuroblastoma cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540000
- author
- Pettersson, Helen LU ; Karlsson, Jenny LU ; Pietras, Alexander LU ; Øra, Ingrid LU and Påhlman, Sven LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Neuroblastoma, Arsenic trioxide, Cell death, APL, Bax
- in
- Journal of Bioenergetics and Biomembranes
- volume
- 39
- issue
- 1
- pages
- 35 - 41
- publisher
- Springer
- external identifiers
-
- wos:000247375900005
- scopus:34249945646
- ISSN
- 1573-6881
- DOI
- 10.1007/s10863-006-9058-6
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Molecular Medicine (013031200)
- id
- 84850dd3-241f-44e5-a3db-217f05e56710 (old id 540000)
- date added to LUP
- 2016-04-01 11:56:38
- date last changed
- 2022-01-26 20:32:49
@article{84850dd3-241f-44e5-a3db-217f05e56710,
abstract = {{The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the children with neuroblastoma have an aggressive form, there is a compelling demand for new treatment strategies. Arsenic trioxide has the capacity to kill multidrug-resistant neuro-blastoma cells in vitro and in vivo and the drug is currently being evaluated in clinical trials. In this report we discuss the background to the use of arsenic trioxide in cancer therapy and the currently known mechanisms by which arsenic trioxide kills human neuroblastoma cells.}},
author = {{Pettersson, Helen and Karlsson, Jenny and Pietras, Alexander and Øra, Ingrid and Påhlman, Sven}},
issn = {{1573-6881}},
keywords = {{Neuroblastoma; Arsenic trioxide; Cell death; APL; Bax}},
language = {{eng}},
number = {{1}},
pages = {{35--41}},
publisher = {{Springer}},
series = {{Journal of Bioenergetics and Biomembranes}},
title = {{Arsenic trioxide and neuroblastoma cytotoxicity.}},
url = {{https://lup.lub.lu.se/search/files/2712953/626022.pdf}},
doi = {{10.1007/s10863-006-9058-6}},
volume = {{39}},
year = {{2007}},
}