Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial : a post hoc analysis
Bohm, Mattias LU
; Årestedt, Kristofer
LU
; Ullén, Susann
LU
; Nielsen, Niklas
LU
; Dankiewicz, Josef
LU
; Friberg, Hans
LU
; Nordström, Erik Blennow
LU
; Cariou, Alain
; Jakobsen, Janus Christian
and Grejs, Anders Morten
, et al.
(2025)
In Resuscitation Plus
24.
- Abstract
Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.
Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal... (More)
Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.
Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal Cognitive Assessment, representing functional outcome and cognitive function—two common health challenges experienced by OHCA survivors.
Results: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61–0.90). We observed a significant but negligible effect of age on Mobility (β = 0.29, p < 0.001, ΔR2 = 0.019). Internal consistency was 0.88. The floor effect was 35%. Survivors with more functional dependency and/or cognitive problems reported significantly worse health by EQ LSS, EQ value, and EQ VAS (all, p < 0.001).
Conclusion: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample.
(Less)- Abstract (Swedish)
- Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.
Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal... (More) - Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.
Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal Cognitive Assessment, representing functional outcome and cognitive function—two common health challenges experienced by OHCA survivors.
Results: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61–0.90). We observed a significant but negligible effect of age on Mobility (b = 0.29, p < 0.001, DR2 = 0.019). Internal consistency was 0.88. The floor effect was 35%. Survivors with more functional dependency and/or cognitive problems reported significantly worse health by EQ LSS, EQ value, and EQ VAS (all, p < 0.001).
Conclusion: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample. (Less)
- author
- Bohm, Mattias
LU
; Årestedt, Kristofer
LU
; Ullén, Susann
LU
; Nielsen, Niklas
LU
; Dankiewicz, Josef
LU
; Friberg, Hans
LU
; Nordström, Erik Blennow
LU
; Cariou, Alain
; Jakobsen, Janus Christian
and Grejs, Anders Morten
, et al. (More)
- Bohm, Mattias
LU
; Årestedt, Kristofer
LU
; Ullén, Susann
LU
; Nielsen, Niklas
LU
; Dankiewicz, Josef
LU
; Friberg, Hans
LU
; Nordström, Erik Blennow
LU
; Cariou, Alain
; Jakobsen, Janus Christian
; Grejs, Anders Morten
; Haenggi, Matthias
; Hammond, Naomi E.
; Heimburg, Katarina
LU
; Keeble, Thomas R.
; Leithner, Christoph
; Rylander, Christian
; Undén, Johan
LU
; Wise, Matt P.
; Cronberg, Tobias
LU
and Lilja, Gisela
LU
(Less)
- organization
-
- Brain Injury After Cardiac Arrest (research group)
- Clinical Sciences, Helsingborg
- SEBRA Sepsis and Bacterial Resistance Alliance (research group)
- Center for cardiac arrest (research group)
- Anesthesiology and Intensive Care
- Cardiology
- SWECRIT (research group)
- Neurology, Lund
- Anaesthesiology and Intensive Care Medicine (research group)
- publishing date
- 2025-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cross-sectional studies, Health status, Heart arrest, Patient reported outcome measures, Psychometrics, Validation study, Cardiac arrest, Depression, Anxiety, PTSD, Psychological, Mental illness
- in
- Resuscitation Plus
- volume
- 24
- article number
- 100994
- publisher
- Elsevier
- external identifiers
-
- scopus:105007469351
- pmid:40530409
- ISSN
- 2666-5204
- DOI
- 10.1016/j.resplu.2025.100994
- project
- Health-related quality of life after out-of-hospital cardiac arrest
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 The Author(s)
- id
- 5651589c-e4a9-42fe-94b3-1b214d2b913b
- date added to LUP
- 2025-06-19 13:20:06
- date last changed
- 2025-07-17 16:26:33
@article{5651589c-e4a9-42fe-94b3-1b214d2b913b,
abstract = {{<p>Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.</p><p>Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal Cognitive Assessment, representing functional outcome and cognitive function—two common health challenges experienced by OHCA survivors.</p><p>Results: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61–0.90). We observed a significant but negligible effect of age on Mobility (β = 0.29, p < 0.001, ΔR<sup>2</sup> = 0.019). Internal consistency was 0.88. The floor effect was 35%. Survivors with more functional dependency and/or cognitive problems reported significantly worse health by EQ LSS, EQ value, and EQ VAS (all, p < 0.001). </p><p>Conclusion: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample.</p>}},
author = {{Bohm, Mattias and Årestedt, Kristofer and Ullén, Susann and Nielsen, Niklas and Dankiewicz, Josef and Friberg, Hans and Nordström, Erik Blennow and Cariou, Alain and Jakobsen, Janus Christian and Grejs, Anders Morten and Haenggi, Matthias and Hammond, Naomi E. and Heimburg, Katarina and Keeble, Thomas R. and Leithner, Christoph and Rylander, Christian and Undén, Johan and Wise, Matt P. and Cronberg, Tobias and Lilja, Gisela}},
issn = {{2666-5204}},
keywords = {{Cross-sectional studies; Health status; Heart arrest; Patient reported outcome measures; Psychometrics; Validation study; Cardiac arrest; Depression; Anxiety; PTSD; Psychological; Mental illness}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Resuscitation Plus}},
title = {{Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial : a post hoc analysis}},
url = {{http://dx.doi.org/10.1016/j.resplu.2025.100994}},
doi = {{10.1016/j.resplu.2025.100994}},
volume = {{24}},
year = {{2025}},
}