The role of phylogenetics in discerning hiv-1 mixing among vulnerable populations and geographic regions in sub-saharan africa : A systematic review
(2021) In Viruses 13(6).- Abstract
To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1... (More)
To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges.
(Less)
- author
- Nduva, George M. LU ; Nazziwa, Jamirah LU ; Hassan, Amin S. LU ; Sanders, Eduard J. and Esbjörnsson, Joakim LU
- organization
- publishing date
- 2021-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HIV-1, Mixed epidemics, Phylogenetics, Sub-Saharan Africa, Transmission dynamics
- in
- Viruses
- volume
- 13
- issue
- 6
- article number
- 1174
- publisher
- MDPI AG
- external identifiers
-
- scopus:85108976084
- pmid:34205246
- ISSN
- 1999-4915
- DOI
- 10.3390/v13061174
- language
- English
- LU publication?
- yes
- id
- 567bdd9b-162c-44a3-bf57-9364abfa410d
- date added to LUP
- 2021-08-20 10:24:26
- date last changed
- 2024-07-27 19:10:25
@article{567bdd9b-162c-44a3-bf57-9364abfa410d, abstract = {{<p>To reduce global HIV-1 incidence, there is a need to understand and disentangle HIV-1 transmission dynamics and to determine the geographic areas and populations that act as hubs or drivers of HIV-1 spread. In Sub-Saharan Africa (sSA), the region with the highest HIV-1 burden, information about such transmission dynamics is sparse. Phylogenetic inference is a powerful method for the study of HIV-1 transmission networks and source attribution. In this review, we assessed available phylogenetic data on mixing between HIV-1 hotspots (geographic areas and populations with high HIV-1 incidence and prevalence) and areas or populations with lower HIV-1 burden in sSA. We searched PubMed and identified and reviewed 64 studies on HIV-1 transmission dynamics within and between risk groups and geographic locations in sSA (published 1995–2021). We describe HIV-1 transmission from both a geographic and a risk group perspective in sSA. Finally, we discuss the challenges facing phylogenetic inference in mixed epidemics in sSA and offer our perspectives and potential solutions to the identified challenges.</p>}}, author = {{Nduva, George M. and Nazziwa, Jamirah and Hassan, Amin S. and Sanders, Eduard J. and Esbjörnsson, Joakim}}, issn = {{1999-4915}}, keywords = {{HIV-1; Mixed epidemics; Phylogenetics; Sub-Saharan Africa; Transmission dynamics}}, language = {{eng}}, number = {{6}}, publisher = {{MDPI AG}}, series = {{Viruses}}, title = {{The role of phylogenetics in discerning hiv-1 mixing among vulnerable populations and geographic regions in sub-saharan africa : A systematic review}}, url = {{http://dx.doi.org/10.3390/v13061174}}, doi = {{10.3390/v13061174}}, volume = {{13}}, year = {{2021}}, }