Impact of a short-term Mediterranean diet intervention on plasma metabolites : a pilot study
(2024) In Metabolomics 20(4).- Abstract
Background: Dietary habits significantly influence the risks of type 2 diabetes and cardiovascular disease. Through metabolomics, we’ve previously measured plasma metabolites to gauge dietary quality, introducing a healthy dietary metabolic signature (HDMS) linked to a decreased risk of future type 2 diabetes and coronary artery disease. Objectives: To assess the impact of a 6-day dietary intervention on plasma metabolites and the HDMS. Methods: Fifty-nine Swedish participants (71% women, mean age 69 years) underwent a 6-day Mediterranean diet (MD) intervention in Italy’s Cilento region. All meals, crafted from local recipes and ingredients, were provided. Metabolite profiling pre- and post-intervention was conducted with a UHPLC-QTOF.... (More)
Background: Dietary habits significantly influence the risks of type 2 diabetes and cardiovascular disease. Through metabolomics, we’ve previously measured plasma metabolites to gauge dietary quality, introducing a healthy dietary metabolic signature (HDMS) linked to a decreased risk of future type 2 diabetes and coronary artery disease. Objectives: To assess the impact of a 6-day dietary intervention on plasma metabolites and the HDMS. Methods: Fifty-nine Swedish participants (71% women, mean age 69 years) underwent a 6-day Mediterranean diet (MD) intervention in Italy’s Cilento region. All meals, crafted from local recipes and ingredients, were provided. Metabolite profiling pre- and post-intervention was conducted with a UHPLC-QTOF. Alterations in metabolite levels and the HDMS were examined using paired T-test. Results: The MD intervention notably enhanced the HDMS across participants (mean increase: 1.3 standard deviations (SD), 95% CI 1.1–1.4, p = 6E-25). Out of 109 metabolites, 66 exhibited significant alterations (fdr adjusted p < 0.05). Among the 10 most significant changes, increases were observed in several diet related metabolites such as pipecolate, hippurate, caffeine, homostachydrine, acylcarnitine C11:0, acetylornithine, beta-carotene and 7-methylguanine. The most significant decreases manifested in piperine and 3-methylhistidine. Conclusions: The HDMS, which is linked to a healthy diet and inversely associated with cardiometabolic disease, was significantly improved by the 6-day Mediterranean diet intervention. Notably, metabolite markers previously shown to be indicative of the intake of vegetables, fruits, grains, and legumes increased, while markers previously associated with red meat consumption decreased. These findings highlight the potential of short-term dietary interventions to induce significant changes in plasma metabolite profiles.
(Less)
- author
- organization
-
- Cardiovascular Research - Hypertension (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Diabetes - Cardiovascular Disease (research group)
- EpiHealth: Epidemiology for Health
- Internal Medicine - Epidemiology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2024-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiovascular disease, Mediterranean diet, Nutrition, Nutritional metabolomics, Type 2 diabetes
- in
- Metabolomics
- volume
- 20
- issue
- 4
- article number
- 82
- publisher
- Springer
- external identifiers
-
- scopus:85199857793
- pmid:39066903
- ISSN
- 1573-3882
- DOI
- 10.1007/s11306-024-02154-7
- language
- English
- LU publication?
- yes
- id
- 5b6c80ca-b1df-45bc-96e5-6b9c2d01b224
- date added to LUP
- 2024-09-09 14:33:47
- date last changed
- 2024-09-23 16:55:10
@article{5b6c80ca-b1df-45bc-96e5-6b9c2d01b224, abstract = {{<p>Background: Dietary habits significantly influence the risks of type 2 diabetes and cardiovascular disease. Through metabolomics, we’ve previously measured plasma metabolites to gauge dietary quality, introducing a healthy dietary metabolic signature (HDMS) linked to a decreased risk of future type 2 diabetes and coronary artery disease. Objectives: To assess the impact of a 6-day dietary intervention on plasma metabolites and the HDMS. Methods: Fifty-nine Swedish participants (71% women, mean age 69 years) underwent a 6-day Mediterranean diet (MD) intervention in Italy’s Cilento region. All meals, crafted from local recipes and ingredients, were provided. Metabolite profiling pre- and post-intervention was conducted with a UHPLC-QTOF. Alterations in metabolite levels and the HDMS were examined using paired T-test. Results: The MD intervention notably enhanced the HDMS across participants (mean increase: 1.3 standard deviations (SD), 95% CI 1.1–1.4, p = 6E-25). Out of 109 metabolites, 66 exhibited significant alterations (fdr adjusted p < 0.05). Among the 10 most significant changes, increases were observed in several diet related metabolites such as pipecolate, hippurate, caffeine, homostachydrine, acylcarnitine C11:0, acetylornithine, beta-carotene and 7-methylguanine. The most significant decreases manifested in piperine and 3-methylhistidine. Conclusions: The HDMS, which is linked to a healthy diet and inversely associated with cardiometabolic disease, was significantly improved by the 6-day Mediterranean diet intervention. Notably, metabolite markers previously shown to be indicative of the intake of vegetables, fruits, grains, and legumes increased, while markers previously associated with red meat consumption decreased. These findings highlight the potential of short-term dietary interventions to induce significant changes in plasma metabolite profiles.</p>}}, author = {{Smith, E. and Ottosson, F. and Ericson, U. and Hellstrand, S. and Rizzo, M. and Sukruang, K. and Pizza, V. and Orho-Melander, M. and Nilsson, P. M. and Kennbäck, C. and Fernandez, C. and Antonini, P. and Di Somma, S. and Melander, O.}}, issn = {{1573-3882}}, keywords = {{Cardiovascular disease; Mediterranean diet; Nutrition; Nutritional metabolomics; Type 2 diabetes}}, language = {{eng}}, number = {{4}}, publisher = {{Springer}}, series = {{Metabolomics}}, title = {{Impact of a short-term Mediterranean diet intervention on plasma metabolites : a pilot study}}, url = {{http://dx.doi.org/10.1007/s11306-024-02154-7}}, doi = {{10.1007/s11306-024-02154-7}}, volume = {{20}}, year = {{2024}}, }