Higher blood pressure in adolescent boys after very preterm birth and fetal growth restriction
(2023) In Pediatric Research 93(7). p.2019-2027- Abstract
- Background
Although preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).
Methods
Adolescents (14 (13–17) years; 52% girls) born very preterm with FGR (preterm FGR; n = 24) and two control groups born with appropriate birth weight (AGA), one in similar gestation (preterm AGA; n = 27) and one at term (term AGA; n = 28) were included. 24-hour ambulatory blood pressure and aortic pulse wave velocity (PWV) and distensibility by magnetic resonance imaging were... (More) - Background
Although preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).
Methods
Adolescents (14 (13–17) years; 52% girls) born very preterm with FGR (preterm FGR; n = 24) and two control groups born with appropriate birth weight (AGA), one in similar gestation (preterm AGA; n = 27) and one at term (term AGA; n = 28) were included. 24-hour ambulatory blood pressure and aortic pulse wave velocity (PWV) and distensibility by magnetic resonance imaging were acquired.
Results
There were no group differences in prevalence of hypertension or in arterial stiffness (all p ≥ 0.1). In boys, diastolic and mean arterial blood pressures increased from term AGA to preterm AGA to preterm FGR with higher daytime and 24-hour mean arterial blood pressures in the preterm FGR as compared to the term AGA group. In girls, no group differences were observed (all p ≥ 0.1).
Conclusions
Very preterm birth due to FGR is associated with higher, yet normal blood pressure in adolescent boys, suggesting an existing but limited impact of very preterm birth on cardiovascular risk in adolescence, enhanced by male sex and FGR.
Impact
Very preterm birth due to fetal growth restriction was associated with higher, yet normal blood pressure in adolescent boys.
In adolescence, very preterm birth due to fetal growth restriction was not associated with increased thoracic aortic stiffness.
In adolescence, very preterm birth in itself showed an existing but limited effect on blood pressure and thoracic aortic stiffness.
Male sex and fetal growth restriction enhanced the effect of preterm birth on blood pressure in adolescence.
Male sex and fetal growth restriction should be considered as additional risk factors to that of preterm birth in cardiovascular risk stratification. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5c7626a8-bae4-41f7-b60f-69f6319d1be8
- author
- Liefke, Jonas
LU
; Steding-Ehrenborg, Katarina
LU
; Sjöberg, Pia
LU
; Ryd, Daniel
LU
; Morsing, Eva
LU
; Arheden, Håkan
LU
; Ley, David
LU
and Hedström, Erik
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- volume
- 93
- issue
- 7
- pages
- 2019 - 2027
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- scopus:85141509927
- pmid:36344695
- ISSN
- 1530-0447
- DOI
- 10.1038/s41390-022-02367-3
- project
- Very preterm birth and fetal growth restriction in adolescence - Cardiovascular and renal aspects
- language
- English
- LU publication?
- yes
- id
- 5c7626a8-bae4-41f7-b60f-69f6319d1be8
- date added to LUP
- 2022-11-08 09:41:00
- date last changed
- 2024-06-13 20:33:46
@article{5c7626a8-bae4-41f7-b60f-69f6319d1be8, abstract = {{Background<br/>Although preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).<br/><br/>Methods<br/>Adolescents (14 (13–17) years; 52% girls) born very preterm with FGR (preterm FGR; n = 24) and two control groups born with appropriate birth weight (AGA), one in similar gestation (preterm AGA; n = 27) and one at term (term AGA; n = 28) were included. 24-hour ambulatory blood pressure and aortic pulse wave velocity (PWV) and distensibility by magnetic resonance imaging were acquired.<br/><br/>Results<br/>There were no group differences in prevalence of hypertension or in arterial stiffness (all p ≥ 0.1). In boys, diastolic and mean arterial blood pressures increased from term AGA to preterm AGA to preterm FGR with higher daytime and 24-hour mean arterial blood pressures in the preterm FGR as compared to the term AGA group. In girls, no group differences were observed (all p ≥ 0.1).<br/><br/>Conclusions<br/>Very preterm birth due to FGR is associated with higher, yet normal blood pressure in adolescent boys, suggesting an existing but limited impact of very preterm birth on cardiovascular risk in adolescence, enhanced by male sex and FGR.<br/><br/>Impact<br/>Very preterm birth due to fetal growth restriction was associated with higher, yet normal blood pressure in adolescent boys.<br/><br/>In adolescence, very preterm birth due to fetal growth restriction was not associated with increased thoracic aortic stiffness.<br/><br/>In adolescence, very preterm birth in itself showed an existing but limited effect on blood pressure and thoracic aortic stiffness.<br/><br/>Male sex and fetal growth restriction enhanced the effect of preterm birth on blood pressure in adolescence.<br/><br/>Male sex and fetal growth restriction should be considered as additional risk factors to that of preterm birth in cardiovascular risk stratification.}}, author = {{Liefke, Jonas and Steding-Ehrenborg, Katarina and Sjöberg, Pia and Ryd, Daniel and Morsing, Eva and Arheden, Håkan and Ley, David and Hedström, Erik}}, issn = {{1530-0447}}, language = {{eng}}, number = {{7}}, pages = {{2019--2027}}, publisher = {{International Pediatric Foundation Inc.}}, series = {{Pediatric Research}}, title = {{Higher blood pressure in adolescent boys after very preterm birth and fetal growth restriction}}, url = {{http://dx.doi.org/10.1038/s41390-022-02367-3}}, doi = {{10.1038/s41390-022-02367-3}}, volume = {{93}}, year = {{2023}}, }