Serum biomarkers in patients with hand-arm vibration injury and in controls
(2024) In Scientific Reports 14. p.1-10- Abstract
Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective... (More)
Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.
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- author
- Tekavec, Eva LU ; Nilsson, Tohr ; Dahlin, Lars B LU ; Huynh, Elizabeth LU ; Axmon, Anna LU ; Nordander, Catarina LU ; Riddar, Jakob LU and Kåredal, Monica LU
- organization
-
- Work-related musculoskeletal disorders (research group)
- EpiHealth: Epidemiology for Health
- WCMM-Wallenberg Centre for Molecular Medicine
- Hand Surgery, Malmö (research group)
- EPI@LUND (research group)
- Metalund
- LU Profile Area: Light and Materials
- LTH Profile Area: Aerosols
- LTH Profile Area: Nanoscience and Semiconductor Technology
- Genetic Occupational and Environmental Medicine (research group)
- NanoLund: Centre for Nanoscience
- publishing date
- 2024-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 14
- article number
- 2719
- pages
- 1 - 10
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85183693560
- pmid:38302542
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-52782-1
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- 5e43cc91-107a-4c87-9e9f-7485c9003960
- date added to LUP
- 2024-02-05 07:37:43
- date last changed
- 2024-10-03 11:58:14
@article{5e43cc91-107a-4c87-9e9f-7485c9003960, abstract = {{<p>Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.</p>}}, author = {{Tekavec, Eva and Nilsson, Tohr and Dahlin, Lars B and Huynh, Elizabeth and Axmon, Anna and Nordander, Catarina and Riddar, Jakob and Kåredal, Monica}}, issn = {{2045-2322}}, language = {{eng}}, month = {{02}}, pages = {{1--10}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Serum biomarkers in patients with hand-arm vibration injury and in controls}}, url = {{http://dx.doi.org/10.1038/s41598-024-52782-1}}, doi = {{10.1038/s41598-024-52782-1}}, volume = {{14}}, year = {{2024}}, }