Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Unfolding the Mystery of Autoimmunity : The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Rewers, Marian ; Agardh, Daniel LU ; Johnson, Suzanne Bennett LU ; Bonifacio, Ezio ; Larsson, Helena Elding LU orcid ; Gesualdo, Patricia ; Hagopian, William ; Haller, Michael J ; Hyöty, Heikki and Johnson, Randi , et al. (2025) In Diabetes Care p.1-11
Abstract

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune diseases has been elusive due to poor understanding of the environmental causes and their... (More)

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune diseases has been elusive due to poor understanding of the environmental causes and their interactions with common predisposing or protective genetic variants. In 2002, the NIDDK established The Environmental Determinants of Diabetes in the Young (TEDDY) consortium to advance understanding of the causes and the natural history of type 1 diabetes and other autoimmune diseases. The overarching goal of TEDDY is to inform novel approaches to primary prevention of autoimmunity. In this large international prospective birth cohort study, standardized information has been collected concerning candidate environmental exposures along with serial blood, stool, nasal swab, and other biosamples, with creation of a central repository of data and biologic samples for hypothesis-based research. This review summarizes TEDDY's major contributions to our understanding of environmental triggers, drivers, and modifiers of autoimmunity, and gene-environment interactions, leading to type 1 diabetes.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
author collaboration
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Diabetes Care
article number
dc242886
pages
1 - 11
publisher
American Diabetes Association
external identifiers
  • pmid:40272272
ISSN
1935-5548
DOI
10.2337/dc24-2886
language
English
LU publication?
yes
additional info
© 2025 by the American Diabetes Association.
id
5eeea64f-c18b-463e-a256-1a2658a5bf42
date added to LUP
2025-04-27 16:35:05
date last changed
2025-04-28 08:38:08
@article{5eeea64f-c18b-463e-a256-1a2658a5bf42,
  abstract     = {{<p>In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune diseases has been elusive due to poor understanding of the environmental causes and their interactions with common predisposing or protective genetic variants. In 2002, the NIDDK established The Environmental Determinants of Diabetes in the Young (TEDDY) consortium to advance understanding of the causes and the natural history of type 1 diabetes and other autoimmune diseases. The overarching goal of TEDDY is to inform novel approaches to primary prevention of autoimmunity. In this large international prospective birth cohort study, standardized information has been collected concerning candidate environmental exposures along with serial blood, stool, nasal swab, and other biosamples, with creation of a central repository of data and biologic samples for hypothesis-based research. This review summarizes TEDDY's major contributions to our understanding of environmental triggers, drivers, and modifiers of autoimmunity, and gene-environment interactions, leading to type 1 diabetes.</p>}},
  author       = {{Rewers, Marian and Agardh, Daniel and Johnson, Suzanne Bennett and Bonifacio, Ezio and Larsson, Helena Elding and Gesualdo, Patricia and Hagopian, William and Haller, Michael J and Hyöty, Heikki and Johnson, Randi and McIndoe, Richard and McKinney, Eoin and Melin, Jessica and Lernmark, Åke and Lloyd, Richard E and Lynch, Kristian F and Norris, Jill M and Rich, Stephen S and Roth, Roswith and Schatz, Desmond and Toppari, Jorma and Triplett, Eric and Vehik, Kendra and Virtanen, Suvi M and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{1--11}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Unfolding the Mystery of Autoimmunity : The Environmental Determinants of Diabetes in the Young (TEDDY) Study}},
  url          = {{http://dx.doi.org/10.2337/dc24-2886}},
  doi          = {{10.2337/dc24-2886}},
  year         = {{2025}},
}