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Heterogeneous Distribution and Absorbed Dose of Radiolabeled Nanoparticles and Colloids in Sentinel Lymph Nodes

Madru, Renata LU ; Larsson, Erik LU ; Örbom, Anders LU orcid ; Ingvar, Christian LU ; Grabau, Dorthe LU ; Knutsson, Linda LU orcid and Strand, Sven-Erik LU (2025) In Cancer Biotherapy and Radiopharmaceuticals 40(4). p.254-262
Abstract
Background: For breast cancer staging, radiolabeled colloids and superparamagnetic iron oxide nanoparticles (SPIONs) are used for sentinel lymph node (SLN) imaging. This study characterized the intranodal activity distribution and absorbed dose distribution. Material and Methods: Six patients diagnosed with primary breast cancer were intradermally injected with 99mTc-Nanocoll. The SLNs were resected, weighed, and measured for activity. Three groups of six rats were subcutaneously injected into the hind paw with either 99mTc-Nanocoll, 99mTc-SPIONs, or 68Ga-SPIONs. Macro- and small-scale dosimetry calculations were performed using autoradiography images of cryosections of SLNs from patients and animals. Results: The mean absorbed dose in... (More)
Background: For breast cancer staging, radiolabeled colloids and superparamagnetic iron oxide nanoparticles (SPIONs) are used for sentinel lymph node (SLN) imaging. This study characterized the intranodal activity distribution and absorbed dose distribution. Material and Methods: Six patients diagnosed with primary breast cancer were intradermally injected with 99mTc-Nanocoll. The SLNs were resected, weighed, and measured for activity. Three groups of six rats were subcutaneously injected into the hind paw with either 99mTc-Nanocoll, 99mTc-SPIONs, or 68Ga-SPIONs. Macro- and small-scale dosimetry calculations were performed using autoradiography images of cryosections of SLNs from patients and animals. Results: The mean absorbed dose in patient SLNs was 0.5?±?0.3 mGy/MBq for 99mTc-Nanocoll and 3.4?±?1.8 mGy/MBq, assuming a 99mTc-Nanocoll-based distribution of 68Ga-SPIONs. Due to different decay characteristics, the heterogeneity in the absorbed dose differed between 99mTc-SPIONs and 68Ga-SPIONs with a maximum to mean absorbed dose ratio of 2.7?±?0.3 and 1.6?±?0.2, respectively. Conclusions: This study shows that 99mTc- and 68Ga-SPIONs and 99mTc-nanocolloids have similar activity distribution in human and animal lymph nodes. Small-scale dosimetry models combined with clinical patient biokinetics may serve as a bridge between organ and tissue dosimetry and the interpretation of intrinsic geometric variation and its uncertainties in absorbed dose. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Biotherapy and Radiopharmaceuticals
volume
40
issue
4
pages
254 - 262
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:40000017
  • scopus:85218876058
ISSN
1084-9785
DOI
10.1089/cbr.2024.0111
language
English
LU publication?
yes
additional info
doi: 10.1089/cbr.2024.0111
id
6533df95-de0f-4869-bbe3-226f0fcffd28
date added to LUP
2025-02-26 07:34:52
date last changed
2025-07-03 10:52:42
@article{6533df95-de0f-4869-bbe3-226f0fcffd28,
  abstract     = {{Background: For breast cancer staging, radiolabeled colloids and superparamagnetic iron oxide nanoparticles (SPIONs) are used for sentinel lymph node (SLN) imaging. This study characterized the intranodal activity distribution and absorbed dose distribution. Material and Methods: Six patients diagnosed with primary breast cancer were intradermally injected with 99mTc-Nanocoll. The SLNs were resected, weighed, and measured for activity. Three groups of six rats were subcutaneously injected into the hind paw with either 99mTc-Nanocoll, 99mTc-SPIONs, or 68Ga-SPIONs. Macro- and small-scale dosimetry calculations were performed using autoradiography images of cryosections of SLNs from patients and animals. Results: The mean absorbed dose in patient SLNs was 0.5?±?0.3 mGy/MBq for 99mTc-Nanocoll and 3.4?±?1.8 mGy/MBq, assuming a 99mTc-Nanocoll-based distribution of 68Ga-SPIONs. Due to different decay characteristics, the heterogeneity in the absorbed dose differed between 99mTc-SPIONs and 68Ga-SPIONs with a maximum to mean absorbed dose ratio of 2.7?±?0.3 and 1.6?±?0.2, respectively. Conclusions: This study shows that 99mTc- and 68Ga-SPIONs and 99mTc-nanocolloids have similar activity distribution in human and animal lymph nodes. Small-scale dosimetry models combined with clinical patient biokinetics may serve as a bridge between organ and tissue dosimetry and the interpretation of intrinsic geometric variation and its uncertainties in absorbed dose.}},
  author       = {{Madru, Renata and Larsson, Erik and Örbom, Anders and Ingvar, Christian and Grabau, Dorthe and Knutsson, Linda and Strand, Sven-Erik}},
  issn         = {{1084-9785}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{254--262}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cancer Biotherapy and Radiopharmaceuticals}},
  title        = {{Heterogeneous Distribution and Absorbed Dose of Radiolabeled Nanoparticles and Colloids in Sentinel Lymph Nodes}},
  url          = {{http://dx.doi.org/10.1089/cbr.2024.0111}},
  doi          = {{10.1089/cbr.2024.0111}},
  volume       = {{40}},
  year         = {{2025}},
}