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Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer group randomised trial SSBCG II : I

Killander, Fredrika LU ; Anderson, Harald LU ; Ryden, Stefan ; Möller, Torgil LU ; Aspegrend, Knut ; Ceberg, Jeanette ; Danewid, Christina and Malmström, Per LU (2007) In European Journal of Cancer 43(14). p.2100-2108
Abstract
Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between... (More)
Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between RT + tam and tam was not significant except in the receptor positive subgroup in favour of non-irradiated patients (p = 0.047). The cumulative incidence of systemic disease at 20 years was lower in the RT + Tam arm than in the RT arm, 40% versus 50% (p = 0.047). Conclusion: Postmastectomy radiotherapy significantly reduced loco-regional recurrences, but overall survival was not improved. At 20 years, a lower mortality was recorded for non-irradiated patients treated with tam. (C) 2007 Published by Elsevier Ltd. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
local recurrence, radiotherapy, breast cancer, mastectomy, mortality, long-term, tamoxifen
in
European Journal of Cancer
volume
43
issue
14
pages
2100 - 2108
publisher
Elsevier
external identifiers
  • wos:000250186100019
  • scopus:34548479956
  • pmid:17644330
ISSN
1879-0852
DOI
10.1016/j.ejca.2007.05.026
language
English
LU publication?
yes
id
68ef6c1b-942b-434e-aec1-c1f84a6fe376 (old id 655358)
date added to LUP
2016-04-01 12:25:27
date last changed
2022-04-21 07:16:04
@article{68ef6c1b-942b-434e-aec1-c1f84a6fe376,
  abstract     = {{Aims: To evaluate long-term effects of radiotherapy and tamoxifen after mastectomy on recurrence and survival in stage II breast cancer. Methods: A randomised phase III study with three treatment alternatives. (1) Radiotherapy 50 Gy/2S fractions to chest wall and regional lymph nodes (RT). (2) Radiotherapy and tamoxifen 30 mg/day for one year (RT + tam) and 3. Tamoxifen (tam). Results: 724 postmenopausal women were included between 1978 and 1985 and the trial was close to population based. Follow-up for survival was 23 years. Locoregional recurrences were reduced from 18.5% in the tam arm to 5.3% in the RT + tam arm. Overall mortality at 20 years was 71% in the RT arm, 68% in the RT + tam arm and 62% in the tam arm. The difference between RT + tam and tam was not significant except in the receptor positive subgroup in favour of non-irradiated patients (p = 0.047). The cumulative incidence of systemic disease at 20 years was lower in the RT + Tam arm than in the RT arm, 40% versus 50% (p = 0.047). Conclusion: Postmastectomy radiotherapy significantly reduced loco-regional recurrences, but overall survival was not improved. At 20 years, a lower mortality was recorded for non-irradiated patients treated with tam. (C) 2007 Published by Elsevier Ltd.}},
  author       = {{Killander, Fredrika and Anderson, Harald and Ryden, Stefan and Möller, Torgil and Aspegrend, Knut and Ceberg, Jeanette and Danewid, Christina and Malmström, Per}},
  issn         = {{1879-0852}},
  keywords     = {{local recurrence; radiotherapy; breast cancer; mastectomy; mortality; long-term; tamoxifen}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{2100--2108}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Cancer}},
  title        = {{Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer group randomised trial SSBCG II : I}},
  url          = {{http://dx.doi.org/10.1016/j.ejca.2007.05.026}},
  doi          = {{10.1016/j.ejca.2007.05.026}},
  volume       = {{43}},
  year         = {{2007}},
}