Coronary flow velocity reserve reduction is comparable in patients with erectile dysfunction and in patients with impaired fasting glucose or well-regulated diabetes mellitus
Borgquist, Rasmus LU
; Nilsson, Peter
LU
; Gudmundsson, Petri
; Winter, Reidar
LU
; Leosdottir, Margrét
LU
and Willenheimer, Ronnie
LU
(2007)
In European Journal of Cardiovascular Prevention & Rehabilitation
14(2).
p.258-264
- Abstract
- Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was... (More)
- Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was evaluated using the International Index of Erectile Function (IIEF)-5 questionnaire. Coronary flow velocity reserve in the left anterior descending artery was examined using Doppler ultrasound and intravenous adenosine provocation. Results Coronary flow velocities at rest did not differ between the three groups, but maximum coronary flow velocity was significantly lower in the erectile dysfunction group (P= 0.004) and in the impaired glucose metabolism group (P= 0.019), as compared with controls. There was no difference between the erectile dysfunction and impaired glucose metabolism groups. Coronary flow velocity reserve was reduced in the erectile dysfunction group (P=0.026) compared to controls, but was similar compared to the impaired glucose metabolism group. In multivariate analysis including all groups, erectile dysfunction score was the only independent predictor of reduced coronary flow velocity reserve (P=0.020). Conclusions The magnitude of early coronary endothelial and smooth muscle cell dysfunction in otherwise healthy men with erectile dysfunction was comparable to that of patients with impaired glucose metabolism: a well known risk factor for coronary artery disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/663615
- author
- Borgquist, Rasmus
LU
; Nilsson, Peter
LU
; Gudmundsson, Petri
; Winter, Reidar
LU
; Leosdottir, Margrét
LU
and Willenheimer, Ronnie
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dysfunction, endothelial, risk factors, erectile dysfunction, ischemic heart disease, coronary microcirculation
- in
- European Journal of Cardiovascular Prevention & Rehabilitation
- volume
- 14
- issue
- 2
- pages
- 258 - 264
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000245958000014
- scopus:34247497405
- pmid:17446805
- ISSN
- 1741-8275
- DOI
- 10.1097/HJR.0b013e328021072b
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Cardiology (013230026), Department of Clinical Sciences, Lund (013230000), Cardiology Research Group (013242120), Department of Medical History (013023200), Internal Medicine Research Unit (013242520)
- id
- 79282a02-aede-4ff0-bac5-2a2058feb5a0 (old id 663615)
- alternative location
- http://www.jcardiovascularrisk.com/pt/re/ejcpr/abstract.00149831-200704000-00014.htm
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17446805&dopt=Abstract
- date added to LUP
- 2016-04-01 11:53:55
- date last changed
- 2022-01-26 19:53:51
@article{79282a02-aede-4ff0-bac5-2a2058feb5a0,
abstract = {{Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compared with men with impaired glucose metabolism (impaired fasting glucose or diabetes) and healthy controls. Methods We investigated men aged 68-73 years with erectile dysfunction (n=12), age-matched men with impaired glucose metabolism, who all proved to have erectile dysfunction (n=15), and age-matched male controls (n=12). Erectile dysfunction was evaluated using the International Index of Erectile Function (IIEF)-5 questionnaire. Coronary flow velocity reserve in the left anterior descending artery was examined using Doppler ultrasound and intravenous adenosine provocation. Results Coronary flow velocities at rest did not differ between the three groups, but maximum coronary flow velocity was significantly lower in the erectile dysfunction group (P= 0.004) and in the impaired glucose metabolism group (P= 0.019), as compared with controls. There was no difference between the erectile dysfunction and impaired glucose metabolism groups. Coronary flow velocity reserve was reduced in the erectile dysfunction group (P=0.026) compared to controls, but was similar compared to the impaired glucose metabolism group. In multivariate analysis including all groups, erectile dysfunction score was the only independent predictor of reduced coronary flow velocity reserve (P=0.020). Conclusions The magnitude of early coronary endothelial and smooth muscle cell dysfunction in otherwise healthy men with erectile dysfunction was comparable to that of patients with impaired glucose metabolism: a well known risk factor for coronary artery disease.}},
author = {{Borgquist, Rasmus and Nilsson, Peter and Gudmundsson, Petri and Winter, Reidar and Leosdottir, Margrét and Willenheimer, Ronnie}},
issn = {{1741-8275}},
keywords = {{dysfunction; endothelial; risk factors; erectile dysfunction; ischemic heart disease; coronary microcirculation}},
language = {{eng}},
number = {{2}},
pages = {{258--264}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Cardiovascular Prevention & Rehabilitation}},
title = {{Coronary flow velocity reserve reduction is comparable in patients with erectile dysfunction and in patients with impaired fasting glucose or well-regulated diabetes mellitus}},
url = {{http://dx.doi.org/10.1097/HJR.0b013e328021072b}},
doi = {{10.1097/HJR.0b013e328021072b}},
volume = {{14}},
year = {{2007}},
}