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A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis

Audard, Vincent ; Hellmark, Thomas LU orcid ; El Karoui, Khalil ; Noel, Laure Helene ; Pardon, Agathe ; Desvaux, Dominique ; Touchard, Guy ; Remy, Philippe ; Lang, Philippe and Sahali, Djillali (2007) In American Journal of Kidney Diseases 49(5). p.710-716
Abstract
Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
goodpasture disease, anti-tubular basement membrane antibodies
in
American Journal of Kidney Diseases
volume
49
issue
5
pages
710 - 716
publisher
Elsevier
external identifiers
  • wos:000248570100021
  • scopus:34247530390
ISSN
1523-6838
DOI
10.1053/j.ajkd.2007.02.002
language
English
LU publication?
yes
id
2ece954e-48df-4d4a-b5aa-5e7867e62c58 (old id 689698)
date added to LUP
2016-04-01 11:52:05
date last changed
2025-10-14 11:32:20
@article{2ece954e-48df-4d4a-b5aa-5e7867e62c58,
  abstract     = {{Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.}},
  author       = {{Audard, Vincent and Hellmark, Thomas and El Karoui, Khalil and Noel, Laure Helene and Pardon, Agathe and Desvaux, Dominique and Touchard, Guy and Remy, Philippe and Lang, Philippe and Sahali, Djillali}},
  issn         = {{1523-6838}},
  keywords     = {{goodpasture disease; anti-tubular basement membrane antibodies}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{710--716}},
  publisher    = {{Elsevier}},
  series       = {{American Journal of Kidney Diseases}},
  title        = {{A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis}},
  url          = {{http://dx.doi.org/10.1053/j.ajkd.2007.02.002}},
  doi          = {{10.1053/j.ajkd.2007.02.002}},
  volume       = {{49}},
  year         = {{2007}},
}