Models for control of intravenous anesthesia
(2020) p.119-166- Abstract
- Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical... (More)
- Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical pharmacology; anesthesia modeling and identification for closed-loop control; inter-patient variability and model uncertainty; disturbance, noise and equipment models. The chapter emphasizes electroencephalogram-guided control of propofol. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/718f3ce7-12d3-447b-9e8b-9f08438d03cc
- author
- Soltesz, Kristian LU ; van Heusden, Klaske and Dumont, Guy A.
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Automated drug delivery in anesthesia
- pages
- 48 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85092226777
- ISBN
- 9780128159767
- 9780128159750
- DOI
- 10.1016/B978-0-12-815975-0.00010-2
- project
- Anesthesia in Closed Loop
- Hemodynamic Stabilization
- language
- English
- LU publication?
- yes
- id
- 718f3ce7-12d3-447b-9e8b-9f08438d03cc
- date added to LUP
- 2019-08-13 09:03:16
- date last changed
- 2024-09-23 18:25:46
@inbook{718f3ce7-12d3-447b-9e8b-9f08438d03cc, abstract = {{Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical pharmacology; anesthesia modeling and identification for closed-loop control; inter-patient variability and model uncertainty; disturbance, noise and equipment models. The chapter emphasizes electroencephalogram-guided control of propofol.}}, author = {{Soltesz, Kristian and van Heusden, Klaske and Dumont, Guy A.}}, booktitle = {{Automated drug delivery in anesthesia}}, isbn = {{9780128159767}}, language = {{eng}}, pages = {{119--166}}, publisher = {{Elsevier}}, title = {{Models for control of intravenous anesthesia}}, url = {{https://lup.lub.lu.se/search/files/83468216/soltesz20c.pdf}}, doi = {{10.1016/B978-0-12-815975-0.00010-2}}, year = {{2020}}, }