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Association between serum levels of testosterone and biomarkers of subclinical atherosclerosis

Rezanezhad, Babak ; Borgquist, Rasmus LU orcid ; Willenheimer, Ronnie and Elzanaty, Saad LU (2018) In Aging Male 21(3). p.182-186
Abstract

Objective: To investigate the association between serum levels of testosterone and biomarkers of subclinical atherosclerosis based on data from 119 middle-aged men of the general population. Methods: Testosterone, Apolipoprotein A-1 (ApoA-1), Apolipoprotein B (ApoB), Apolipoprotein B-to-Apolipoprotein A-1 ratio (ApoB-to-ApoA-1), high-sensitive C-reactive protein (hsCRP), and fibrinogen levels were measured. Data were also gathered based on age, BMI, waist circumference, smoking, alcohol consumption, and family history of cardiovascular diseases. Men were classified into two groups based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal men (testosterone >12 nmol/L). Results: When compared to eugonadal, the... (More)

Objective: To investigate the association between serum levels of testosterone and biomarkers of subclinical atherosclerosis based on data from 119 middle-aged men of the general population. Methods: Testosterone, Apolipoprotein A-1 (ApoA-1), Apolipoprotein B (ApoB), Apolipoprotein B-to-Apolipoprotein A-1 ratio (ApoB-to-ApoA-1), high-sensitive C-reactive protein (hsCRP), and fibrinogen levels were measured. Data were also gathered based on age, BMI, waist circumference, smoking, alcohol consumption, and family history of cardiovascular diseases. Men were classified into two groups based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal men (testosterone >12 nmol/L). Results: When compared to eugonadal, the hypogonadal men were significantly older (56 years vs. 55 years, p = .03), had greater BMI (28 kg/cm2 vs. 26 kg/cm2, p = .01), and higher waist circumference (104 cm vs. 100 cm, p = .01). Moreover, ApoB, ApoB-to-ApoA-1 ratio, and hsCRP were significantly higher in hypogonadal men compared to eugonadal men (1.1 g/L vs. 1.0 g/L, p = .03), (0.8 vs. 0.7, p = .03), (3.3 mg/L vs. 2.0 mg/L, p = .01), respectively. On the other hand, ApoA-1 and fibrinogen levels did not differ significantly between groups (p > .05). In an adjusted multivariate regression analysis model, only ApoB showed a significant negative association with testosterone levels (β = −0.01; 95% CI = −0.02, −1.50; p = .04). Conclusion: Testosterone levels showed an inverse relation to ApoB, a biomarker implicated in subclinical atherosclerosis. These findings support the hypothesis that low testosterone levels play a role in atherosclerosis.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, eugonadal, hypogonadal, subclinical, testosterone
in
Aging Male
volume
21
issue
3
pages
182 - 186
publisher
Informa Healthcare
external identifiers
  • pmid:29272977
  • scopus:85038875215
ISSN
1368-5538
DOI
10.1080/13685538.2017.1412422
language
English
LU publication?
yes
id
76140565-e03e-40b3-80a1-aaf67c18ecb5
date added to LUP
2018-01-02 15:31:21
date last changed
2025-04-15 09:18:48
@article{76140565-e03e-40b3-80a1-aaf67c18ecb5,
  abstract     = {{<p>Objective: To investigate the association between serum levels of testosterone and biomarkers of subclinical atherosclerosis based on data from 119 middle-aged men of the general population. Methods: Testosterone, Apolipoprotein A-1 (ApoA-1), Apolipoprotein B (ApoB), Apolipoprotein B-to-Apolipoprotein A-1 ratio (ApoB-to-ApoA-1), high-sensitive C-reactive protein (hsCRP), and fibrinogen levels were measured. Data were also gathered based on age, BMI, waist circumference, smoking, alcohol consumption, and family history of cardiovascular diseases. Men were classified into two groups based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal men (testosterone &gt;12 nmol/L). Results: When compared to eugonadal, the hypogonadal men were significantly older (56 years vs. 55 years, p = .03), had greater BMI (28 kg/cm<sup>2</sup> vs. 26 kg/cm<sup>2</sup>, p = .01), and higher waist circumference (104 cm vs. 100 cm, p = .01). Moreover, ApoB, ApoB-to-ApoA-1 ratio, and hsCRP were significantly higher in hypogonadal men compared to eugonadal men (1.1 g/L vs. 1.0 g/L, p = .03), (0.8 vs. 0.7, p = .03), (3.3 mg/L vs. 2.0 mg/L, p = .01), respectively. On the other hand, ApoA-1 and fibrinogen levels did not differ significantly between groups (p &gt; .05). In an adjusted multivariate regression analysis model, only ApoB showed a significant negative association with testosterone levels (β = −0.01; 95% CI = −0.02, −1.50; p = .04). Conclusion: Testosterone levels showed an inverse relation to ApoB, a biomarker implicated in subclinical atherosclerosis. These findings support the hypothesis that low testosterone levels play a role in atherosclerosis.</p>}},
  author       = {{Rezanezhad, Babak and Borgquist, Rasmus and Willenheimer, Ronnie and Elzanaty, Saad}},
  issn         = {{1368-5538}},
  keywords     = {{Atherosclerosis; eugonadal; hypogonadal; subclinical; testosterone}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{3}},
  pages        = {{182--186}},
  publisher    = {{Informa Healthcare}},
  series       = {{Aging Male}},
  title        = {{Association between serum levels of testosterone and biomarkers of subclinical atherosclerosis}},
  url          = {{http://dx.doi.org/10.1080/13685538.2017.1412422}},
  doi          = {{10.1080/13685538.2017.1412422}},
  volume       = {{21}},
  year         = {{2018}},
}