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Mitochondrial respiratory states and rates

Gnaiger, Erich ; Åsander Frostner, Eleonor LU orcid ; Ehinger, Johannes LU orcid ; Elmer, Eskil LU orcid ; Piel, Sarah LU orcid and Zvejniece, Liga (2019) In MitoFit Preprint Arch
Abstract
As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow guidelines of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven... (More)
As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow guidelines of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of databases of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery. (Less)
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published
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keywords
mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, uncoupling, oxidative phosphorylation: OXPHOS, efficiency, electron transfer: ET, electron transfer system: ETS, proton leak, ion leak and slip compensatory state: LEAK, residual oxygen consumption: ROX, State 2, State 3, State 4, normalization, flow, flux, oxygen: O2
in
MitoFit Preprint Arch
publisher
MitoFit Preprints
DOI
10.26124/mitofit:190001.v3
project
EU FP Horizon 2020 COST Action CA15203 MITOEAGLE
language
English
LU publication?
yes
id
79c1d4f5-7bfa-4fb5-a2b7-a407932bcdd6
date added to LUP
2019-05-07 11:44:21
date last changed
2021-12-03 13:47:40
@misc{79c1d4f5-7bfa-4fb5-a2b7-a407932bcdd6,
  abstract     = {{As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow guidelines of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of databases of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.}},
  author       = {{Gnaiger, Erich and Åsander Frostner, Eleonor and Ehinger, Johannes and Elmer, Eskil and Piel, Sarah and Zvejniece, Liga}},
  keywords     = {{mitochondrial respiratory control; coupling control; mitochondrial preparations; protonmotive force; uncoupling; oxidative phosphorylation: OXPHOS; efficiency; electron transfer: ET; electron transfer system: ETS; proton leak; ion leak and slip compensatory state: LEAK; residual oxygen consumption: ROX; State 2; State 3; State 4; normalization; flow; flux; oxygen: O2}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{MitoFit Preprints}},
  series       = {{MitoFit Preprint Arch}},
  title        = {{Mitochondrial respiratory states and rates}},
  url          = {{http://dx.doi.org/10.26124/mitofit:190001.v3}},
  doi          = {{10.26124/mitofit:190001.v3}},
  year         = {{2019}},
}