Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden
(2024) In Scientific Reports 14.- Abstract
- Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this study were to investigate the impact of PP elevation on incident CKD (glomerular filtration rate < 60 ml/min/1.73 m2) and all-cause mortality. The data was collected from the general population cohort study “Good Aging in Skåne”. Cox proportional hazard regression models adjusted for age, sex, diabetes, and smoking habits were used to investigate... (More)
- Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this study were to investigate the impact of PP elevation on incident CKD (glomerular filtration rate < 60 ml/min/1.73 m2) and all-cause mortality. The data was collected from the general population cohort study “Good Aging in Skåne”. Cox proportional hazard regression models adjusted for age, sex, diabetes, and smoking habits were used to investigate the impact of three levels of PP elevation on incident CKD (n = 2693) and all-cause mortality (n = 5253). For PP < 60 mmHg, the median survival time was 18.7 years (event incident CKD) and first quartile survival time (event all-cause mortality) 15.4 years. Elevated PP ≥ 80 mmHg was associated with incident CKD (hazard ratio 1.59, CI 1.28–1.97), but not all-cause mortality. Our results suggest that a finding of PP ≥ 80 mmHg in older age should raise concern of kidney function. (Less)
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https://lup.lub.lu.se/record/7bd57c99-2b44-4535-8dc2-be136197281b
- author
- Månsson, Tomas LU ; Rosso, Aldana LU ; Ellström, Katarina LU and Elmståhl, Sölve LU
- organization
- publishing date
- 2024-07-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 14
- article number
- 15414
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:38965357
- scopus:85197502493
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-66458-3
- language
- English
- LU publication?
- yes
- id
- 7bd57c99-2b44-4535-8dc2-be136197281b
- date added to LUP
- 2024-08-09 17:50:04
- date last changed
- 2024-08-12 08:40:47
@article{7bd57c99-2b44-4535-8dc2-be136197281b, abstract = {{Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this study were to investigate the impact of PP elevation on incident CKD (glomerular filtration rate < 60 ml/min/1.73 m2) and all-cause mortality. The data was collected from the general population cohort study “Good Aging in Skåne”. Cox proportional hazard regression models adjusted for age, sex, diabetes, and smoking habits were used to investigate the impact of three levels of PP elevation on incident CKD (n = 2693) and all-cause mortality (n = 5253). For PP < 60 mmHg, the median survival time was 18.7 years (event incident CKD) and first quartile survival time (event all-cause mortality) 15.4 years. Elevated PP ≥ 80 mmHg was associated with incident CKD (hazard ratio 1.59, CI 1.28–1.97), but not all-cause mortality. Our results suggest that a finding of PP ≥ 80 mmHg in older age should raise concern of kidney function.}}, author = {{Månsson, Tomas and Rosso, Aldana and Ellström, Katarina and Elmståhl, Sölve}}, issn = {{2045-2322}}, language = {{eng}}, month = {{07}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden}}, url = {{http://dx.doi.org/10.1038/s41598-024-66458-3}}, doi = {{10.1038/s41598-024-66458-3}}, volume = {{14}}, year = {{2024}}, }