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A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy

Petersson, Kristoffer LU ; Kyroudi, Archonteia ; Bourhis, Jean ; Ceberg, Crister LU orcid ; Knoos, Tommy LU orcid ; Bochud, Francois and Möckli, Raphaël (2017) In Physics and imaging in radiation oncology 3. p.53-56
Abstract
We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics and imaging in radiation oncology
volume
3
pages
53 - 56
publisher
Elsevier
external identifiers
  • scopus:85070485711
ISSN
2405-6316
DOI
10.1016/j.phro.2017.09.003
language
English
LU publication?
yes
id
7e1f2e8d-73bf-453b-990a-a7f59b2b43da
date added to LUP
2019-06-18 10:24:21
date last changed
2022-03-16 23:37:21
@article{7e1f2e8d-73bf-453b-990a-a7f59b2b43da,
  abstract     = {{We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of &gt;0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p &lt; .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.}},
  author       = {{Petersson, Kristoffer and Kyroudi, Archonteia and Bourhis, Jean and Ceberg, Crister and Knoos, Tommy and Bochud, Francois and Möckli, Raphaël}},
  issn         = {{2405-6316}},
  language     = {{eng}},
  pages        = {{53--56}},
  publisher    = {{Elsevier}},
  series       = {{Physics and imaging in radiation oncology}},
  title        = {{A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy}},
  url          = {{http://dx.doi.org/10.1016/j.phro.2017.09.003}},
  doi          = {{10.1016/j.phro.2017.09.003}},
  volume       = {{3}},
  year         = {{2017}},
}