Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2
(2000) In Proceedings of the National Academy of Sciences of the United States of America 97(22). p.12312-12317- Abstract
Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the glycosylphosphatidylinositol-anchored GDNF family receptor (GFR) α1 and α2 in limbic structures. We demonstrate here that epileptogenesis, as assessed in the hippocampal kindling model, is markedly suppressed in mice lacking GFRα2. Moreover, at 6 to 8 wk after having reached the epileptic state, the hyperexcitability is lower in GFRα2 knock-out mice as compared with wild-type mice. These results provide evidence that signaling through GFRα2 is involved in mechanisms regulating the development and persistence of kindling epilepsy. Our data... (More)
Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the glycosylphosphatidylinositol-anchored GDNF family receptor (GFR) α1 and α2 in limbic structures. We demonstrate here that epileptogenesis, as assessed in the hippocampal kindling model, is markedly suppressed in mice lacking GFRα2. Moreover, at 6 to 8 wk after having reached the epileptic state, the hyperexcitability is lower in GFRα2 knock-out mice as compared with wild-type mice. These results provide evidence that signaling through GFRα2 is involved in mechanisms regulating the development and persistence of kindling epilepsy. Our data suggest that GDNF and NRTN may modulate seizure susceptibility by altering the function of hilar neuropeptide Y-containing interneurons and entorhinal cortical afferents at dentate granule cell synapses.
(Less)
- author
- Nanobashvili, Avtandil LU ; Airaksinen, Matti S. ; Kokaia, Merab LU ; Rossi, Jari ; Asztély, Fredrik LU ; Olofsdotter, Klara LU ; Mohapel, Paul LU ; Saarma, Mart ; Lindvall, Olle LU and Kokaia, Zaal LU
- publishing date
- 2000-10-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences of the United States of America
- volume
- 97
- issue
- 22
- pages
- 6 pages
- publisher
- National Academy of Sciences
- external identifiers
-
- pmid:11050250
- scopus:12944293011
- ISSN
- 0027-8424
- DOI
- 10.1073/pnas.97.22.12312
- language
- English
- LU publication?
- no
- id
- 82ce4316-3aa5-41df-ae3d-5db505071129
- date added to LUP
- 2019-09-03 17:00:11
- date last changed
- 2024-02-15 19:56:32
@article{82ce4316-3aa5-41df-ae3d-5db505071129, abstract = {{<p>Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the glycosylphosphatidylinositol-anchored GDNF family receptor (GFR) α1 and α2 in limbic structures. We demonstrate here that epileptogenesis, as assessed in the hippocampal kindling model, is markedly suppressed in mice lacking GFRα2. Moreover, at 6 to 8 wk after having reached the epileptic state, the hyperexcitability is lower in GFRα2 knock-out mice as compared with wild-type mice. These results provide evidence that signaling through GFRα2 is involved in mechanisms regulating the development and persistence of kindling epilepsy. Our data suggest that GDNF and NRTN may modulate seizure susceptibility by altering the function of hilar neuropeptide Y-containing interneurons and entorhinal cortical afferents at dentate granule cell synapses.</p>}}, author = {{Nanobashvili, Avtandil and Airaksinen, Matti S. and Kokaia, Merab and Rossi, Jari and Asztély, Fredrik and Olofsdotter, Klara and Mohapel, Paul and Saarma, Mart and Lindvall, Olle and Kokaia, Zaal}}, issn = {{0027-8424}}, language = {{eng}}, month = {{10}}, number = {{22}}, pages = {{12312--12317}}, publisher = {{National Academy of Sciences}}, series = {{Proceedings of the National Academy of Sciences of the United States of America}}, title = {{Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2}}, url = {{http://dx.doi.org/10.1073/pnas.97.22.12312}}, doi = {{10.1073/pnas.97.22.12312}}, volume = {{97}}, year = {{2000}}, }