Long-term microvascular and blood pressure dysregulation after Preeclampsia
(2025) In Hypertension Research 48(6). p.1972-1982- Abstract
Preeclampsia (PE) is a pregnancy disorder characterized by systemic endothelial damage that leads to long-term cardiovascular complications. The endothelial glycocalyx (EG) covers the luminal surface of endothelium playing a critical role in vascular homeostasis. In this study we aimed to evaluate EG thickness and blood pressure (BP) trends in women with a history of PE vs. normotensive pregnancy. Fifty-five women participated in the study (18 controls, 34 with PE, and 3 with gestational hypertension). Six years postpartum, we evaluated the sublingual microcirculation by sidestream dark-field microscopy, and assessed BP in the sitting and orthostatic position. At follow-up, women with PE had reduced EG thickness in vessels ≥ 8 µm,... (More)
Preeclampsia (PE) is a pregnancy disorder characterized by systemic endothelial damage that leads to long-term cardiovascular complications. The endothelial glycocalyx (EG) covers the luminal surface of endothelium playing a critical role in vascular homeostasis. In this study we aimed to evaluate EG thickness and blood pressure (BP) trends in women with a history of PE vs. normotensive pregnancy. Fifty-five women participated in the study (18 controls, 34 with PE, and 3 with gestational hypertension). Six years postpartum, we evaluated the sublingual microcirculation by sidestream dark-field microscopy, and assessed BP in the sitting and orthostatic position. At follow-up, women with PE had reduced EG thickness in vessels ≥ 8 µm, expressed by an increased perfused boundary region (PBR), compared to healthy controls (median 3.14 vs. 2.88 µm, p = 0.002). A trend towards increased red blood cell velocity in vessels ≥ 10 µm was also observed in PE vs. controls. The systolic and diastolic BP, as well as within-visit BP variability, were significantly higher in PE vs. controls. Adverse neonatal outcomes, umbilical artery Doppler and BP during both the pregnancy and the follow-up visit, were associated with maternal PBR value in vessels ≥ 8 µm. This study contributes to the existing literature on PE and the increased risk of future cardiovascular disease, highlighting the critical role of EG and BP regulatory mechanisms. Our results showed that the severity of hemodynamic and neonatal impairments during pregnancy may irreversibly affect the EG and thereby be associated with long-term maternal vascular dysfunction. (Figure presented.)
(Less)
- author
- Jälmby, Maya
LU
; Edvinsson, Camilla
LU
; Lykou, Despoina
LU
; Karampas, Grigorios LU ; Erlandsson, Lena LU ; Hansson, Stefan R. LU
and Piani, Federica LU
- organization
- publishing date
- 2025-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Endothelial dysfunction, Glycocalyx, Hypertension, Hypertensive disorders of pregnancy, Preeclampsia
- in
- Hypertension Research
- volume
- 48
- issue
- 6
- pages
- 11 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:40175678
- scopus:105001678305
- ISSN
- 0916-9636
- DOI
- 10.1038/s41440-025-02176-1
- language
- English
- LU publication?
- yes
- id
- 8a17c178-9eed-492c-a061-6706192055d8
- date added to LUP
- 2025-09-04 10:11:30
- date last changed
- 2025-09-18 11:02:58
@article{8a17c178-9eed-492c-a061-6706192055d8, abstract = {{<p>Preeclampsia (PE) is a pregnancy disorder characterized by systemic endothelial damage that leads to long-term cardiovascular complications. The endothelial glycocalyx (EG) covers the luminal surface of endothelium playing a critical role in vascular homeostasis. In this study we aimed to evaluate EG thickness and blood pressure (BP) trends in women with a history of PE vs. normotensive pregnancy. Fifty-five women participated in the study (18 controls, 34 with PE, and 3 with gestational hypertension). Six years postpartum, we evaluated the sublingual microcirculation by sidestream dark-field microscopy, and assessed BP in the sitting and orthostatic position. At follow-up, women with PE had reduced EG thickness in vessels ≥ 8 µm, expressed by an increased perfused boundary region (PBR), compared to healthy controls (median 3.14 vs. 2.88 µm, p = 0.002). A trend towards increased red blood cell velocity in vessels ≥ 10 µm was also observed in PE vs. controls. The systolic and diastolic BP, as well as within-visit BP variability, were significantly higher in PE vs. controls. Adverse neonatal outcomes, umbilical artery Doppler and BP during both the pregnancy and the follow-up visit, were associated with maternal PBR value in vessels ≥ 8 µm. This study contributes to the existing literature on PE and the increased risk of future cardiovascular disease, highlighting the critical role of EG and BP regulatory mechanisms. Our results showed that the severity of hemodynamic and neonatal impairments during pregnancy may irreversibly affect the EG and thereby be associated with long-term maternal vascular dysfunction. (Figure presented.)</p>}}, author = {{Jälmby, Maya and Edvinsson, Camilla and Lykou, Despoina and Karampas, Grigorios and Erlandsson, Lena and Hansson, Stefan R. and Piani, Federica}}, issn = {{0916-9636}}, keywords = {{Endothelial dysfunction; Glycocalyx; Hypertension; Hypertensive disorders of pregnancy; Preeclampsia}}, language = {{eng}}, number = {{6}}, pages = {{1972--1982}}, publisher = {{Nature Publishing Group}}, series = {{Hypertension Research}}, title = {{Long-term microvascular and blood pressure dysregulation after Preeclampsia}}, url = {{http://dx.doi.org/10.1038/s41440-025-02176-1}}, doi = {{10.1038/s41440-025-02176-1}}, volume = {{48}}, year = {{2025}}, }